Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study

Raul Zamora-Ros, Jazmín Castañeda, Sabina Rinaldi, Valerie Cayssials, Nadia Slimani, Elisabete Weiderpass, Konstantinos K. Tsilidis, Marie Christine Boutron-Ruault, Kim Overvad, Anne K. Eriksen, Anne Tjønneland, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Anastasia Kotanidou, Domenico Palli, Sara Grioni, Amalia MattielloRosario Tumino, Veronica Sciannameo, Eiliv Lund, Susana Merino, Elena Salamanca-Fernández, Pilar Amiano, José María Huerta, Aurelio Barricarte, Ulrika Ericson, Martin Almquist, Joakim Hennings, Maria Sandström, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Kay Tee Khaw, Nicholas J. Wareham, Julie A. Schmidt, Amanda J. Cross, Elio Riboli, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Silvia Franceschi

Research output: Contribution to journalArticle

Abstract

Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.

Original languageEnglish
Pages (from-to)1366-1373
Number of pages8
JournalJournal of Nutrition
Volume147
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Thyroid Neoplasms
Fishes
Shellfish
Neoplasms
Fish Products
Iodine
Endocrine Gland Neoplasms
Micronutrients
Thyroid Gland
Incidence

Keywords

  • Cohort
  • EPIC
  • Fish
  • Intake
  • Thyroid cancer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study. / Zamora-Ros, Raul; Castañeda, Jazmín; Rinaldi, Sabina; Cayssials, Valerie; Slimani, Nadia; Weiderpass, Elisabete; Tsilidis, Konstantinos K.; Boutron-Ruault, Marie Christine; Overvad, Kim; Eriksen, Anne K.; Tjønneland, Anne; Kühn, Tilman; Katzke, Verena; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Kotanidou, Anastasia; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Sciannameo, Veronica; Lund, Eiliv; Merino, Susana; Salamanca-Fernández, Elena; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Ericson, Ulrika; Almquist, Martin; Hennings, Joakim; Sandström, Maria; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Khaw, Kay Tee; Wareham, Nicholas J.; Schmidt, Julie A.; Cross, Amanda J.; Riboli, Elio; Scalbert, Augustin; Romieu, Isabelle; Agudo, Antonio; Franceschi, Silvia.

In: Journal of Nutrition, Vol. 147, No. 7, 01.07.2017, p. 1366-1373.

Research output: Contribution to journalArticle

Zamora-Ros, R, Castañeda, J, Rinaldi, S, Cayssials, V, Slimani, N, Weiderpass, E, Tsilidis, KK, Boutron-Ruault, MC, Overvad, K, Eriksen, AK, Tjønneland, A, Kühn, T, Katzke, V, Boeing, H, Trichopoulou, A, La Vecchia, C, Kotanidou, A, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Sciannameo, V, Lund, E, Merino, S, Salamanca-Fernández, E, Amiano, P, Huerta, JM, Barricarte, A, Ericson, U, Almquist, M, Hennings, J, Sandström, M, Bueno-de-Mesquita, HB, Peeters, PH, Khaw, KT, Wareham, NJ, Schmidt, JA, Cross, AJ, Riboli, E, Scalbert, A, Romieu, I, Agudo, A & Franceschi, S 2017, 'Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study', Journal of Nutrition, vol. 147, no. 7, pp. 1366-1373. https://doi.org/10.3945/jn.117.247874
Zamora-Ros, Raul ; Castañeda, Jazmín ; Rinaldi, Sabina ; Cayssials, Valerie ; Slimani, Nadia ; Weiderpass, Elisabete ; Tsilidis, Konstantinos K. ; Boutron-Ruault, Marie Christine ; Overvad, Kim ; Eriksen, Anne K. ; Tjønneland, Anne ; Kühn, Tilman ; Katzke, Verena ; Boeing, Heiner ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Kotanidou, Anastasia ; Palli, Domenico ; Grioni, Sara ; Mattiello, Amalia ; Tumino, Rosario ; Sciannameo, Veronica ; Lund, Eiliv ; Merino, Susana ; Salamanca-Fernández, Elena ; Amiano, Pilar ; Huerta, José María ; Barricarte, Aurelio ; Ericson, Ulrika ; Almquist, Martin ; Hennings, Joakim ; Sandström, Maria ; Bueno-de-Mesquita, H. Bas ; Peeters, Petra H. ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Schmidt, Julie A. ; Cross, Amanda J. ; Riboli, Elio ; Scalbert, Augustin ; Romieu, Isabelle ; Agudo, Antonio ; Franceschi, Silvia. / Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study. In: Journal of Nutrition. 2017 ; Vol. 147, No. 7. pp. 1366-1373.
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abstract = "Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95{\%} CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95{\%} CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.",
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author = "Raul Zamora-Ros and Jazm{\'i}n Casta{\~n}eda and Sabina Rinaldi and Valerie Cayssials and Nadia Slimani and Elisabete Weiderpass and Tsilidis, {Konstantinos K.} and Boutron-Ruault, {Marie Christine} and Kim Overvad and Eriksen, {Anne K.} and Anne Tj{\o}nneland and Tilman K{\"u}hn and Verena Katzke and Heiner Boeing and Antonia Trichopoulou and {La Vecchia}, Carlo and Anastasia Kotanidou and Domenico Palli and Sara Grioni and Amalia Mattiello and Rosario Tumino and Veronica Sciannameo and Eiliv Lund and Susana Merino and Elena Salamanca-Fern{\'a}ndez and Pilar Amiano and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Ulrika Ericson and Martin Almquist and Joakim Hennings and Maria Sandstr{\"o}m and Bueno-de-Mesquita, {H. Bas} and Peeters, {Petra H.} and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Schmidt, {Julie A.} and Cross, {Amanda J.} and Elio Riboli and Augustin Scalbert and Isabelle Romieu and Antonio Agudo and Silvia Franceschi",
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T1 - Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study

AU - Zamora-Ros, Raul

AU - Castañeda, Jazmín

AU - Rinaldi, Sabina

AU - Cayssials, Valerie

AU - Slimani, Nadia

AU - Weiderpass, Elisabete

AU - Tsilidis, Konstantinos K.

AU - Boutron-Ruault, Marie Christine

AU - Overvad, Kim

AU - Eriksen, Anne K.

AU - Tjønneland, Anne

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Kotanidou, Anastasia

AU - Palli, Domenico

AU - Grioni, Sara

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sciannameo, Veronica

AU - Lund, Eiliv

AU - Merino, Susana

AU - Salamanca-Fernández, Elena

AU - Amiano, Pilar

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Ericson, Ulrika

AU - Almquist, Martin

AU - Hennings, Joakim

AU - Sandström, Maria

AU - Bueno-de-Mesquita, H. Bas

AU - Peeters, Petra H.

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Schmidt, Julie A.

AU - Cross, Amanda J.

AU - Riboli, Elio

AU - Scalbert, Augustin

AU - Romieu, Isabelle

AU - Agudo, Antonio

AU - Franceschi, Silvia

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.

AB - Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.

KW - Cohort

KW - EPIC

KW - Fish

KW - Intake

KW - Thyroid cancer

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DO - 10.3945/jn.117.247874

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