Consumption of vegetables and fruits and risk of breast cancer

Carla H. Van Gils, Petra H M Peeters, H. Bas Bueno-de-Mesquita, Hendriek C. Boshuizen, Petra H. Lahmann, Françoise Clavel-Chapelon, Anne Thiébaut, Emmanuelle Kesse, Sabina Sieri, Domenico Palli, Rosario Tumino, Salvatore Panico, Paolo Vineis, Carlos A. Gonzalez, Eva Ardanaz, Maria José Sánchez, Pilar Amiano, Carmen Navarro, José R. Quirós, Timothy J. Key & 23 others Naomi Allen, Kay Tee Khaw, Sheila A. Bingham, Theodora Psaltopoulou, Maria Koliva, Antonia Trichopoulou, Gabriële Nagel, Jakob Linseisen, Heiner Boeing, Göran Berglund, Elisabet Wirfält, Göran Hallmans, Per Lenner, Kim Overvad, Anne Tjønneland, Anja Olsen, Eiliv Lund, Dagrun Engeset, Elin Alsaker, Teresa Norat, Rudolf Kaaks, Nadia Slimani, Elio Riboli

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Context: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. Design, Setting, and Participants Prospective study of 285526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. Main Outcome Measures: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. Results: During 1486402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI, 0.94-1.25) for total fruit, and 1.05 (95% CI, 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. Conclusion: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer.

Original languageEnglish
Pages (from-to)183-193
Number of pages11
JournalJournal of the American Medical Association
Volume293
Issue number2
DOIs
Publication statusPublished - Jan 12 2005

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Vegetables
Fruit
Breast Neoplasms
Confidence Intervals
Incidence
Case-Control Studies
Neoplasms
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Van Gils, C. H., Peeters, P. H. M., Bueno-de-Mesquita, H. B., Boshuizen, H. C., Lahmann, P. H., Clavel-Chapelon, F., ... Riboli, E. (2005). Consumption of vegetables and fruits and risk of breast cancer. Journal of the American Medical Association, 293(2), 183-193. https://doi.org/10.1001/jama.293.2.183

Consumption of vegetables and fruits and risk of breast cancer. / Van Gils, Carla H.; Peeters, Petra H M; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C.; Lahmann, Petra H.; Clavel-Chapelon, Françoise; Thiébaut, Anne; Kesse, Emmanuelle; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Panico, Salvatore; Vineis, Paolo; Gonzalez, Carlos A.; Ardanaz, Eva; Sánchez, Maria José; Amiano, Pilar; Navarro, Carmen; Quirós, José R.; Key, Timothy J.; Allen, Naomi; Khaw, Kay Tee; Bingham, Sheila A.; Psaltopoulou, Theodora; Koliva, Maria; Trichopoulou, Antonia; Nagel, Gabriële; Linseisen, Jakob; Boeing, Heiner; Berglund, Göran; Wirfält, Elisabet; Hallmans, Göran; Lenner, Per; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Lund, Eiliv; Engeset, Dagrun; Alsaker, Elin; Norat, Teresa; Kaaks, Rudolf; Slimani, Nadia; Riboli, Elio.

In: Journal of the American Medical Association, Vol. 293, No. 2, 12.01.2005, p. 183-193.

Research output: Contribution to journalArticle

Van Gils, CH, Peeters, PHM, Bueno-de-Mesquita, HB, Boshuizen, HC, Lahmann, PH, Clavel-Chapelon, F, Thiébaut, A, Kesse, E, Sieri, S, Palli, D, Tumino, R, Panico, S, Vineis, P, Gonzalez, CA, Ardanaz, E, Sánchez, MJ, Amiano, P, Navarro, C, Quirós, JR, Key, TJ, Allen, N, Khaw, KT, Bingham, SA, Psaltopoulou, T, Koliva, M, Trichopoulou, A, Nagel, G, Linseisen, J, Boeing, H, Berglund, G, Wirfält, E, Hallmans, G, Lenner, P, Overvad, K, Tjønneland, A, Olsen, A, Lund, E, Engeset, D, Alsaker, E, Norat, T, Kaaks, R, Slimani, N & Riboli, E 2005, 'Consumption of vegetables and fruits and risk of breast cancer', Journal of the American Medical Association, vol. 293, no. 2, pp. 183-193. https://doi.org/10.1001/jama.293.2.183
Van Gils CH, Peeters PHM, Bueno-de-Mesquita HB, Boshuizen HC, Lahmann PH, Clavel-Chapelon F et al. Consumption of vegetables and fruits and risk of breast cancer. Journal of the American Medical Association. 2005 Jan 12;293(2):183-193. https://doi.org/10.1001/jama.293.2.183
Van Gils, Carla H. ; Peeters, Petra H M ; Bueno-de-Mesquita, H. Bas ; Boshuizen, Hendriek C. ; Lahmann, Petra H. ; Clavel-Chapelon, Françoise ; Thiébaut, Anne ; Kesse, Emmanuelle ; Sieri, Sabina ; Palli, Domenico ; Tumino, Rosario ; Panico, Salvatore ; Vineis, Paolo ; Gonzalez, Carlos A. ; Ardanaz, Eva ; Sánchez, Maria José ; Amiano, Pilar ; Navarro, Carmen ; Quirós, José R. ; Key, Timothy J. ; Allen, Naomi ; Khaw, Kay Tee ; Bingham, Sheila A. ; Psaltopoulou, Theodora ; Koliva, Maria ; Trichopoulou, Antonia ; Nagel, Gabriële ; Linseisen, Jakob ; Boeing, Heiner ; Berglund, Göran ; Wirfält, Elisabet ; Hallmans, Göran ; Lenner, Per ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja ; Lund, Eiliv ; Engeset, Dagrun ; Alsaker, Elin ; Norat, Teresa ; Kaaks, Rudolf ; Slimani, Nadia ; Riboli, Elio. / Consumption of vegetables and fruits and risk of breast cancer. In: Journal of the American Medical Association. 2005 ; Vol. 293, No. 2. pp. 183-193.
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title = "Consumption of vegetables and fruits and risk of breast cancer",
abstract = "Context: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. Design, Setting, and Participants Prospective study of 285526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. Main Outcome Measures: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. Results: During 1486402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95{\%} confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95{\%} CI, 0.94-1.25) for total fruit, and 1.05 (95{\%} CI, 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. Conclusion: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer.",
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T1 - Consumption of vegetables and fruits and risk of breast cancer

AU - Van Gils, Carla H.

AU - Peeters, Petra H M

AU - Bueno-de-Mesquita, H. Bas

AU - Boshuizen, Hendriek C.

AU - Lahmann, Petra H.

AU - Clavel-Chapelon, Françoise

AU - Thiébaut, Anne

AU - Kesse, Emmanuelle

AU - Sieri, Sabina

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Vineis, Paolo

AU - Gonzalez, Carlos A.

AU - Ardanaz, Eva

AU - Sánchez, Maria José

AU - Amiano, Pilar

AU - Navarro, Carmen

AU - Quirós, José R.

AU - Key, Timothy J.

AU - Allen, Naomi

AU - Khaw, Kay Tee

AU - Bingham, Sheila A.

AU - Psaltopoulou, Theodora

AU - Koliva, Maria

AU - Trichopoulou, Antonia

AU - Nagel, Gabriële

AU - Linseisen, Jakob

AU - Boeing, Heiner

AU - Berglund, Göran

AU - Wirfält, Elisabet

AU - Hallmans, Göran

AU - Lenner, Per

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Lund, Eiliv

AU - Engeset, Dagrun

AU - Alsaker, Elin

AU - Norat, Teresa

AU - Kaaks, Rudolf

AU - Slimani, Nadia

AU - Riboli, Elio

PY - 2005/1/12

Y1 - 2005/1/12

N2 - Context: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. Design, Setting, and Participants Prospective study of 285526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. Main Outcome Measures: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. Results: During 1486402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI, 0.94-1.25) for total fruit, and 1.05 (95% CI, 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. Conclusion: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer.

AB - Context: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. Design, Setting, and Participants Prospective study of 285526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. Main Outcome Measures: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. Results: During 1486402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI, 0.94-1.25) for total fruit, and 1.05 (95% CI, 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. Conclusion: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer.

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