Contact dermatitis to cocamidopropylbetaine is caused by residual amines: Relevance, clinical characteristics, and review of the literature

Paolo D. Pigatto, Andrea S. Bigardi, Francesco Cusano

Research output: Contribution to journalArticle

Abstract

Cocamidopropylbetaine (CAPE) is an amphoteric surfactant mainly sold as Tegobetaine L7; it is often included in shampoos, cleansing lotions, and disinfectants. In the last 2 years, this was responsible for 15 cases of allergic contact dermatitis seen in our clinics. The causes were shampoos, face cleansing lotions, gynecological antiseptic syndets, liquid shower soaps, and anal hygienic detergents. Although there are only a few cases of contact dermatitis reported in the literature from CAPB and detergents are generally considered rare sensitizing agents, the sensitizing potential of CAPB may be greater than previously thought. This seems to be because of a contaminant, dimethylaminopropylamine, found in some of the cosmetic products.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalAmerican Journal of Contact Dermatitis
Volume6
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Dermatology

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