Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis

M. Veroux, D. Corona, V. Scriffignano, P. Caglià, M. Gagliano, G. Giuffrida, F. Gona, A. Sciacca, A. Giaquinta, S. Oliveri, N. Sinagra, T. Tallarita, D. Zerbo, M. Sorbello, L. Parrinello, P. Veroux

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: Contamination of preservation fluid is common, with a reported incidence of 2.2% to 28.0%, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. Materials and Methods: We analyzed 62 samples of preservation fluid for microbial and fungal contamination. Results: Twenty-four samples (38.7%) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. Conclusion: Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed.

Original languageEnglish
Pages (from-to)1043-1045
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number4
DOIs
Publication statusPublished - May 2010

Fingerprint

Kidney Transplantation
Candida
Transplantation
Ureteral Obstruction
Fluconazole
Therapeutics
Nephrectomy
Acute Kidney Injury
Fungi
Anti-Bacterial Agents
Morbidity
Transplants
Incidence

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Veroux, M., Corona, D., Scriffignano, V., Caglià, P., Gagliano, M., Giuffrida, G., ... Veroux, P. (2010). Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis. Transplantation Proceedings, 42(4), 1043-1045. https://doi.org/10.1016/j.transproceed.2010.03.041

Contamination of Preservation Fluid in Kidney Transplantation : Single-Center Analysis. / Veroux, M.; Corona, D.; Scriffignano, V.; Caglià, P.; Gagliano, M.; Giuffrida, G.; Gona, F.; Sciacca, A.; Giaquinta, A.; Oliveri, S.; Sinagra, N.; Tallarita, T.; Zerbo, D.; Sorbello, M.; Parrinello, L.; Veroux, P.

In: Transplantation Proceedings, Vol. 42, No. 4, 05.2010, p. 1043-1045.

Research output: Contribution to journalArticle

Veroux, M, Corona, D, Scriffignano, V, Caglià, P, Gagliano, M, Giuffrida, G, Gona, F, Sciacca, A, Giaquinta, A, Oliveri, S, Sinagra, N, Tallarita, T, Zerbo, D, Sorbello, M, Parrinello, L & Veroux, P 2010, 'Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis', Transplantation Proceedings, vol. 42, no. 4, pp. 1043-1045. https://doi.org/10.1016/j.transproceed.2010.03.041
Veroux M, Corona D, Scriffignano V, Caglià P, Gagliano M, Giuffrida G et al. Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis. Transplantation Proceedings. 2010 May;42(4):1043-1045. https://doi.org/10.1016/j.transproceed.2010.03.041
Veroux, M. ; Corona, D. ; Scriffignano, V. ; Caglià, P. ; Gagliano, M. ; Giuffrida, G. ; Gona, F. ; Sciacca, A. ; Giaquinta, A. ; Oliveri, S. ; Sinagra, N. ; Tallarita, T. ; Zerbo, D. ; Sorbello, M. ; Parrinello, L. ; Veroux, P. / Contamination of Preservation Fluid in Kidney Transplantation : Single-Center Analysis. In: Transplantation Proceedings. 2010 ; Vol. 42, No. 4. pp. 1043-1045.
@article{b0282a3edcf044889fd39d5bb4a59e12,
title = "Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis",
abstract = "Introduction: Contamination of preservation fluid is common, with a reported incidence of 2.2{\%} to 28.0{\%}, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. Materials and Methods: We analyzed 62 samples of preservation fluid for microbial and fungal contamination. Results: Twenty-four samples (38.7{\%}) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. Conclusion: Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed.",
author = "M. Veroux and D. Corona and V. Scriffignano and P. Cagli{\`a} and M. Gagliano and G. Giuffrida and F. Gona and A. Sciacca and A. Giaquinta and S. Oliveri and N. Sinagra and T. Tallarita and D. Zerbo and M. Sorbello and L. Parrinello and P. Veroux",
year = "2010",
month = "5",
doi = "10.1016/j.transproceed.2010.03.041",
language = "English",
volume = "42",
pages = "1043--1045",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Contamination of Preservation Fluid in Kidney Transplantation

T2 - Single-Center Analysis

AU - Veroux, M.

AU - Corona, D.

AU - Scriffignano, V.

AU - Caglià, P.

AU - Gagliano, M.

AU - Giuffrida, G.

AU - Gona, F.

AU - Sciacca, A.

AU - Giaquinta, A.

AU - Oliveri, S.

AU - Sinagra, N.

AU - Tallarita, T.

AU - Zerbo, D.

AU - Sorbello, M.

AU - Parrinello, L.

AU - Veroux, P.

PY - 2010/5

Y1 - 2010/5

N2 - Introduction: Contamination of preservation fluid is common, with a reported incidence of 2.2% to 28.0%, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. Materials and Methods: We analyzed 62 samples of preservation fluid for microbial and fungal contamination. Results: Twenty-four samples (38.7%) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. Conclusion: Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed.

AB - Introduction: Contamination of preservation fluid is common, with a reported incidence of 2.2% to 28.0%, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. Materials and Methods: We analyzed 62 samples of preservation fluid for microbial and fungal contamination. Results: Twenty-four samples (38.7%) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. Conclusion: Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed.

UR - http://www.scopus.com/inward/record.url?scp=77952558981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952558981&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2010.03.041

DO - 10.1016/j.transproceed.2010.03.041

M3 - Article

C2 - 20534219

AN - SCOPUS:77952558981

VL - 42

SP - 1043

EP - 1045

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 4

ER -