Contemporary and potential future molecular diagnosis of melanoma

G. Gandolfi, K. Dallaglio, C. Longo, E. Moscarella, Aimilios Lallas, R. Alfano, G. Argenziano, A. Ciarrocchi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Introduction: The increasing incidence of cutaneous melanoma and the still limited effective treatments available for this disease represent a major health problem and a great challenge for research. The raise of the “omics” era and the development of new techniques to explore phenotypic heterogeneity are helping to decipher the mechanisms at the basis of melanoma heterogeneity. Areas covered: We reviewed the most recent publications about the biology of cutaneous melanoma, to provide an overview of the most recent insights into the complexity of this tumor and their potential impact in the clinical settings. Expert commentary: Starting from the first attempts to provide a molecular classification of melanoma, it has been evident that this tumor represents a widely heterogeneous disease. This complexity and the multivariate nature of melanoma represent a major obstacle in developing the best management strategies for patients.

Original languageEnglish
Pages (from-to)975-985
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume16
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

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Melanoma
Skin
Neoplasms
Incidence
Health
Research
Therapeutics

Keywords

  • cellular heterogeneity
  • Cutaneous melanoma
  • genetic heterogeneity
  • molecular diagnosis
  • next generation sequencing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Contemporary and potential future molecular diagnosis of melanoma. / Gandolfi, G.; Dallaglio, K.; Longo, C.; Moscarella, E.; Lallas, Aimilios; Alfano, R.; Argenziano, G.; Ciarrocchi, A.

In: Expert Review of Molecular Diagnostics, Vol. 16, No. 9, 01.09.2016, p. 975-985.

Research output: Contribution to journalReview article

Gandolfi, G, Dallaglio, K, Longo, C, Moscarella, E, Lallas, A, Alfano, R, Argenziano, G & Ciarrocchi, A 2016, 'Contemporary and potential future molecular diagnosis of melanoma', Expert Review of Molecular Diagnostics, vol. 16, no. 9, pp. 975-985. https://doi.org/10.1080/14737159.2016.1206473
Gandolfi, G. ; Dallaglio, K. ; Longo, C. ; Moscarella, E. ; Lallas, Aimilios ; Alfano, R. ; Argenziano, G. ; Ciarrocchi, A. / Contemporary and potential future molecular diagnosis of melanoma. In: Expert Review of Molecular Diagnostics. 2016 ; Vol. 16, No. 9. pp. 975-985.
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