Background: We comprehensively tested contemporary incidence and mortality rates in patients with germ cell tumor of the testis (GCTT). Materials and Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2015), statistical analyses included estimated annual percentage changes, multivariable logistic regression (MLR) models, Kaplan–Meier curves, and multivariable Cox regression (MCR) models. Results: Of 13,114 GCTT patients, 7954 (60.6%) harbored seminoma germ cell tumors of the testis (SGCTT) and 5160 (39.4%) non-SGCTT (NSGCTT). Relative to SGCTT, NSGCTT patients harbored more advanced stage (for stage III 824 [16.0%] vs. 279 patients [3.5%]; P <. 001). In MLR, higher rates of stage II/III affected those with never-married status (odds ratio [OR], 1.6; P <. 001) and African American ethnicity (OR, 1.5; P =. 005) for SGCTT and never-married (OR, 1.3; P =. 002) and Hispanic ethnicity (OR, 1.3; P <. 001) for NSGCTT. Significant differences in 5-year cancer-specific mortality (CSM) distinguished SGCTT (stage I: 0.4; stage II: 3.4; stage III: 11.4%; P <. 001) from NSGCTT (stage I: 1.6; stage II: 2.5; stage III: 22.2%; P <. 001). In MCR, unmarried status independently predicted higher CSM for SGCTT (hazard ratio [HR], 2.1; P =. 007) and NSGCTT (HR, 1.9; P <. 001). Conclusion: Stage I and stage III NSGCTT survival is worse, than for SGCTT. Never-married, Hispanic, and African American individuals are at higher risk of more advanced stage and/or CSM in SGCTT and NSGCTT.
- Nonseminoma germ cell tumor
ASJC Scopus subject areas