Contemporary Incidence and Mortality Rates in Patients With Testicular Germ Cell Tumors

Carlotta Palumbo, Francesco A. Mistretta, Elio Mazzone, Sophie Knipper, Zhe Tian, Paul Perrotte, Alessandro Antonelli, Francesco Montorsi, Shahrokh F. Shariat, Fred Saad, Claudio Simeone, Alberto Briganti, Jean Baptiste Lattouf, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We comprehensively tested contemporary incidence and mortality rates in patients with germ cell tumor of the testis (GCTT). Materials and Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2015), statistical analyses included estimated annual percentage changes, multivariable logistic regression (MLR) models, Kaplan–Meier curves, and multivariable Cox regression (MCR) models. Results: Of 13,114 GCTT patients, 7954 (60.6%) harbored seminoma germ cell tumors of the testis (SGCTT) and 5160 (39.4%) non-SGCTT (NSGCTT). Relative to SGCTT, NSGCTT patients harbored more advanced stage (for stage III 824 [16.0%] vs. 279 patients [3.5%]; P <. 001). In MLR, higher rates of stage II/III affected those with never-married status (odds ratio [OR], 1.6; P <. 001) and African American ethnicity (OR, 1.5; P =. 005) for SGCTT and never-married (OR, 1.3; P =. 002) and Hispanic ethnicity (OR, 1.3; P <. 001) for NSGCTT. Significant differences in 5-year cancer-specific mortality (CSM) distinguished SGCTT (stage I: 0.4; stage II: 3.4; stage III: 11.4%; P <. 001) from NSGCTT (stage I: 1.6; stage II: 2.5; stage III: 22.2%; P <. 001). In MCR, unmarried status independently predicted higher CSM for SGCTT (hazard ratio [HR], 2.1; P =. 007) and NSGCTT (HR, 1.9; P <. 001). Conclusion: Stage I and stage III NSGCTT survival is worse, than for SGCTT. Never-married, Hispanic, and African American individuals are at higher risk of more advanced stage and/or CSM in SGCTT and NSGCTT.

Original languageEnglish
Pages (from-to)e1026-e1035
JournalClinical Genitourinary Cancer
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Mortality
  • Nonseminoma germ cell tumor
  • Seminoma
  • Survival
  • Trend

ASJC Scopus subject areas

  • Oncology
  • Urology

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