Contemporary incidence and mortality rates of kidney cancer in the united states

Giorgio Gandaglia, Praful Ravi, Firas Abdollah, Abd El Rahman M Abd-El-Barr, Andreas Becker, Ioana Popa, Alberto Briganti, Pierre I. Karakiewicz, Quoc Dien Trinh, Michael A. Jewett, Maxine Sun

Research output: Contribution to journalArticlepeer-review


Methods: Relying on the Surveillance, Epidemiology, and End Results (SEER) database, we computed age-adjusted incidence, mortality rates and 5-year cancer-specific survival (CSS) for patients with histologically confirmed kidney cancer between 1975 and 2009. Long-term (1975–2009) and short-term (2000–2009) trends were examined by joinpoint analysis, and quantified using the annual percent change (APC). The reported findings were stratified according to disease stage.

Results: Age-adjusted incidence rates of RCC increased by +2.76%/year between 1975 and 2009 (from 6.5 to 17.1/100 000 personyears, p <0.001), and by +2.85%/year between 2000 and 2009 (p <0.001). For the same time points, the corresponding APC for the incidence of localized stage were +4.55%/year (from 3.0 to 12.2/100 000 person years, p <0.001), and +4.42%/year (p <0.001), respectively. The incidence rates of regional stage increased by +0.88%/year between 1975 and 2009 (p <0.001), but stabilized in recent years (2000–2009: +0.56%/year, p = 0.4). Incidence rates of distant stage remained unchanged in long-and short-term trends. Overall mortality rates increased by +1.72%/year between 1975 and 2009 (from 1.2 to 5.0/100 000 person-years, P

Interpretation: In contemporary years, there is a persisting upward trend in incidence and mortality of localized RCC.

Introduction: This is a timely update of incidence and mortality for renal cell carcinoma (RCC) in the United States.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalJournal of the Canadian Urological Association
Issue number7-8 AUGUST
Publication statusPublished - Aug 1 2014

ASJC Scopus subject areas

  • Oncology
  • Urology


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