TY - JOUR
T1 - Contemporary incidence and mortality rates of kidney cancer in the united states
AU - Gandaglia, Giorgio
AU - Ravi, Praful
AU - Abdollah, Firas
AU - Abd-El-Barr, Abd El Rahman M
AU - Becker, Andreas
AU - Popa, Ioana
AU - Briganti, Alberto
AU - Karakiewicz, Pierre I.
AU - Trinh, Quoc Dien
AU - Jewett, Michael A.
AU - Sun, Maxine
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Methods: Relying on the Surveillance, Epidemiology, and End Results (SEER) database, we computed age-adjusted incidence, mortality rates and 5-year cancer-specific survival (CSS) for patients with histologically confirmed kidney cancer between 1975 and 2009. Long-term (1975–2009) and short-term (2000–2009) trends were examined by joinpoint analysis, and quantified using the annual percent change (APC). The reported findings were stratified according to disease stage.Results: Age-adjusted incidence rates of RCC increased by +2.76%/year between 1975 and 2009 (from 6.5 to 17.1/100 000 personyears, p <0.001), and by +2.85%/year between 2000 and 2009 (p <0.001). For the same time points, the corresponding APC for the incidence of localized stage were +4.55%/year (from 3.0 to 12.2/100 000 person years, p <0.001), and +4.42%/year (p <0.001), respectively. The incidence rates of regional stage increased by +0.88%/year between 1975 and 2009 (p <0.001), but stabilized in recent years (2000–2009: +0.56%/year, p = 0.4). Incidence rates of distant stage remained unchanged in long-and short-term trends. Overall mortality rates increased by +1.72%/year between 1975 and 2009 (from 1.2 to 5.0/100 000 person-years, PInterpretation: In contemporary years, there is a persisting upward trend in incidence and mortality of localized RCC.Introduction: This is a timely update of incidence and mortality for renal cell carcinoma (RCC) in the United States.
AB - Methods: Relying on the Surveillance, Epidemiology, and End Results (SEER) database, we computed age-adjusted incidence, mortality rates and 5-year cancer-specific survival (CSS) for patients with histologically confirmed kidney cancer between 1975 and 2009. Long-term (1975–2009) and short-term (2000–2009) trends were examined by joinpoint analysis, and quantified using the annual percent change (APC). The reported findings were stratified according to disease stage.Results: Age-adjusted incidence rates of RCC increased by +2.76%/year between 1975 and 2009 (from 6.5 to 17.1/100 000 personyears, p <0.001), and by +2.85%/year between 2000 and 2009 (p <0.001). For the same time points, the corresponding APC for the incidence of localized stage were +4.55%/year (from 3.0 to 12.2/100 000 person years, p <0.001), and +4.42%/year (p <0.001), respectively. The incidence rates of regional stage increased by +0.88%/year between 1975 and 2009 (p <0.001), but stabilized in recent years (2000–2009: +0.56%/year, p = 0.4). Incidence rates of distant stage remained unchanged in long-and short-term trends. Overall mortality rates increased by +1.72%/year between 1975 and 2009 (from 1.2 to 5.0/100 000 person-years, PInterpretation: In contemporary years, there is a persisting upward trend in incidence and mortality of localized RCC.Introduction: This is a timely update of incidence and mortality for renal cell carcinoma (RCC) in the United States.
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U2 - 10.5489/cuaj.1760
DO - 10.5489/cuaj.1760
M3 - Article
AN - SCOPUS:84919906800
VL - 8
SP - 247
EP - 252
JO - Journal of the Canadian Urological Association
JF - Journal of the Canadian Urological Association
SN - 1911-6470
IS - 7-8 AUGUST
ER -