Contemporary percutaneous treatment of unprotected left main coronary stenoses: Initial results from a multicenter registry analysis 1994-1996

Stephen G. Ellis; Hideo Tamai; Masakiyo Nobuyoshi; Kunihiko Kosuga; Antonio Colombo; David R. Holmes; Carlos Macaya; Cindy L. Grines; Patrick L. Whitlow; Harvey J. White; Jeffrey Moses; Paul S. Teirstein; Patrick W. Serruys; John A. Bittl; Michael R. Mooney; Thomas M. Shimshak; Peter C. Block; Raimund Erbel

Contemporary percutaneous treatment of unprotected left main coronary stenoses: Initial results from a multicenter registry analysis 1994-1996

Stephen G. Ellis, Hideo Tamai, Masakiyo Nobuyoshi, Kunihiko Kosuga, Antonio Colombo, David R. Holmes, Carlos Macaya, Cindy L. Grines, Patrick L. Whitlow, Harvey J. White, Jeffrey Moses, Paul S. Teirstein, Patrick W. Serruys, John A. Bittl, Michael R. Mooney, Thomas M. Shimshak, Peter C. Block, Raimund Erbel

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Coronary artery bypass surgery (CABG) has been considered the therapy of choice for patients with unprotected left main (ULMT) coronary stenoses. Selected single-center reports suggest that the results of percutaneous intervention may now approach those of CABG. Methods and Results: To assess the results of percutaneous ULMT treatment from a wide variety of experienced interventional centers, we requested data on consecutive patients treated after January 1, 1994, from 25 centers. One hundred seven patients were identified who were treated either electively (n=91) or for acute myocardial infarction (n=16). Of patients treated electively, 25% were considered inoperable, and 27% were considered high risk for bypass surgery. Primary treatment included stents (50%), directional atherectomy (24%), and balloon angioplasty (20%). Follow-up was 98.8% complete at 15±8 months. Results varied considerably, depending on presentation and treatment for patients with acute myocardial infarction, technical success was achieved in 75%, and survival to hospital discharge was 31%. For elective patients, technical success was achieved in 98.9%, and in- hospital survival was strongly correlated with left ventricular ejection fraction (P=.003). Longer-term event (death, infarction, or bypass surgery) - free survival was correlated with ejection fraction (P

Original language	English
Pages (from-to)	3867-3872
Number of pages	6
Journal	Circulation
Volume	96
Issue number	11
Publication status	Published - 1997

Keywords

Angioplasty
Arteries
Bypass
Coronary disease
Stents

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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Ellis, S. G., Tamai, H., Nobuyoshi, M., Kosuga, K., Colombo, A., Holmes, D. R., Macaya, C., Grines, C. L., Whitlow, P. L., White, H. J., Moses, J., Teirstein, P. S., Serruys, P. W., Bittl, J. A., Mooney, M. R., Shimshak, T. M., Block, P. C., & Erbel, R. (1997). Contemporary percutaneous treatment of unprotected left main coronary stenoses: Initial results from a multicenter registry analysis 1994-1996. Circulation, 96(11), 3867-3872.

Contemporary percutaneous treatment of unprotected left main coronary stenoses : Initial results from a multicenter registry analysis 1994-1996. / Ellis, Stephen G.; Tamai, Hideo; Nobuyoshi, Masakiyo; Kosuga, Kunihiko; Colombo, Antonio; Holmes, David R.; Macaya, Carlos; Grines, Cindy L.; Whitlow, Patrick L.; White, Harvey J.; Moses, Jeffrey; Teirstein, Paul S.; Serruys, Patrick W.; Bittl, John A.; Mooney, Michael R.; Shimshak, Thomas M.; Block, Peter C.; Erbel, Raimund.

In: Circulation, Vol. 96, No. 11, 1997, p. 3867-3872.

Research output: Contribution to journal › Article › peer-review

Ellis, SG, Tamai, H, Nobuyoshi, M, Kosuga, K, Colombo, A, Holmes, DR, Macaya, C, Grines, CL, Whitlow, PL, White, HJ, Moses, J, Teirstein, PS, Serruys, PW, Bittl, JA, Mooney, MR, Shimshak, TM, Block, PC & Erbel, R 1997, 'Contemporary percutaneous treatment of unprotected left main coronary stenoses: Initial results from a multicenter registry analysis 1994-1996', Circulation, vol. 96, no. 11, pp. 3867-3872.

Ellis, Stephen G. ; Tamai, Hideo ; Nobuyoshi, Masakiyo ; Kosuga, Kunihiko ; Colombo, Antonio ; Holmes, David R. ; Macaya, Carlos ; Grines, Cindy L. ; Whitlow, Patrick L. ; White, Harvey J. ; Moses, Jeffrey ; Teirstein, Paul S. ; Serruys, Patrick W. ; Bittl, John A. ; Mooney, Michael R. ; Shimshak, Thomas M. ; Block, Peter C. ; Erbel, Raimund. / Contemporary percutaneous treatment of unprotected left main coronary stenoses : Initial results from a multicenter registry analysis 1994-1996. In: Circulation. 1997 ; Vol. 96, No. 11. pp. 3867-3872.

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abstract = "Background: Coronary artery bypass surgery (CABG) has been considered the therapy of choice for patients with unprotected left main (ULMT) coronary stenoses. Selected single-center reports suggest that the results of percutaneous intervention may now approach those of CABG. Methods and Results: To assess the results of percutaneous ULMT treatment from a wide variety of experienced interventional centers, we requested data on consecutive patients treated after January 1, 1994, from 25 centers. One hundred seven patients were identified who were treated either electively (n=91) or for acute myocardial infarction (n=16). Of patients treated electively, 25% were considered inoperable, and 27% were considered high risk for bypass surgery. Primary treatment included stents (50%), directional atherectomy (24%), and balloon angioplasty (20%). Follow-up was 98.8% complete at 15±8 months. Results varied considerably, depending on presentation and treatment for patients with acute myocardial infarction, technical success was achieved in 75%, and survival to hospital discharge was 31%. For elective patients, technical success was achieved in 98.9%, and in- hospital survival was strongly correlated with left ventricular ejection fraction (P=.003). Longer-term event (death, infarction, or bypass surgery) - free survival was correlated with ejection fraction (P",

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AU - Ellis, Stephen G.

AU - Tamai, Hideo

AU - Nobuyoshi, Masakiyo

AU - Kosuga, Kunihiko

AU - Colombo, Antonio

AU - Holmes, David R.

AU - Macaya, Carlos

AU - Grines, Cindy L.

AU - Whitlow, Patrick L.

AU - White, Harvey J.

AU - Moses, Jeffrey

AU - Teirstein, Paul S.

AU - Serruys, Patrick W.

AU - Bittl, John A.

AU - Mooney, Michael R.

AU - Shimshak, Thomas M.

AU - Block, Peter C.

AU - Erbel, Raimund

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N2 - Background: Coronary artery bypass surgery (CABG) has been considered the therapy of choice for patients with unprotected left main (ULMT) coronary stenoses. Selected single-center reports suggest that the results of percutaneous intervention may now approach those of CABG. Methods and Results: To assess the results of percutaneous ULMT treatment from a wide variety of experienced interventional centers, we requested data on consecutive patients treated after January 1, 1994, from 25 centers. One hundred seven patients were identified who were treated either electively (n=91) or for acute myocardial infarction (n=16). Of patients treated electively, 25% were considered inoperable, and 27% were considered high risk for bypass surgery. Primary treatment included stents (50%), directional atherectomy (24%), and balloon angioplasty (20%). Follow-up was 98.8% complete at 15±8 months. Results varied considerably, depending on presentation and treatment for patients with acute myocardial infarction, technical success was achieved in 75%, and survival to hospital discharge was 31%. For elective patients, technical success was achieved in 98.9%, and in- hospital survival was strongly correlated with left ventricular ejection fraction (P=.003). Longer-term event (death, infarction, or bypass surgery) - free survival was correlated with ejection fraction (P

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