Contextual bottom-up and implicit top-down modulation of anarchic hand syndrome

A single-case report and a review of the literature

Valentina Moro, Simone Pernigo, Michele Scandola, Maria Mainente, Renato Avesani, Salvatore Maria Aglioti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anarchic hand syndrome (AHS) is a rare neurological condition characterized by seemingly purposeful, goal-directed hand movements which the person afflicted by the syndrome is not, however, in control of. By extensively examining a patient with AHS we provide novel neuropsychological and lesion mapping data that shed new light on the possibility of modulating specific symptoms associated with AHS, in particular unilateral apraxia and magnetic apraxia. Moreover, we compared lesion mapping data with an in depth analysis of previous studies in order to explore the neural network responsible for the complex symptomatology associated with this syndrome. We found that non-primarily motor variables (e.g. the nature of the object to be grasped and integration of visuo-spatial feedback in action) play an important role in determining AHS symptomatology. Moreover, we found that lesions involving various different parts of the motor control network (the corpus callosum, the anterior cingulate cortex and the supplementary motor area, the parietal areas and thalamus) are closely linked to partially differing AHS symptoms. The comparison of our data with those reported in previous studies indicate that AHS is a multifaceted and complex syndrome in which the influence of non-primarily motor, emotional and higher-order components may be largely underestimated.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalNeuropsychologia
Volume78
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Alien Hand Syndrome
Apraxias
Corpus Callosum
Gyrus Cinguli
Motor Cortex
Thalamus
Hand

Keywords

  • Anarchic hand syndrome
  • Dangerous stimulus
  • Magnetic apraxia
  • Unilateral apraxia
  • Visual observation perspective

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Contextual bottom-up and implicit top-down modulation of anarchic hand syndrome : A single-case report and a review of the literature. / Moro, Valentina; Pernigo, Simone; Scandola, Michele; Mainente, Maria; Avesani, Renato; Aglioti, Salvatore Maria.

In: Neuropsychologia, Vol. 78, 01.11.2015, p. 122-129.

Research output: Contribution to journalArticle

Moro, Valentina ; Pernigo, Simone ; Scandola, Michele ; Mainente, Maria ; Avesani, Renato ; Aglioti, Salvatore Maria. / Contextual bottom-up and implicit top-down modulation of anarchic hand syndrome : A single-case report and a review of the literature. In: Neuropsychologia. 2015 ; Vol. 78. pp. 122-129.
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