Contextual-dependent effects of nucleus accumbens lesions on spatial learning in mice

Martine Ammassari-Teule, Leonardo Restivo, Enrica Passino

Research output: Contribution to journalArticlepeer-review


The effect of nucleus accumbens lesions on radial maze performance of C57BL/6 and DBA/2 mice was assessed under distinct extra-maze cuing conditions. Among sham-lesioned mice, C57BL/6 performed better under rich than poor cuing conditions whereas DBA performed in the same fashion under both conditions. In C57BL/6, a disruptive effect of lesions was found only in mice tested under rich cuing. Conversely, in DBA/2, the lesions improved performance under poor cuing and disrupted performance under rich cuing. In that strain, a possible lesion-induced enhancement of attention to background stimuli improving performance under poor cuing but producing interference under rich cuing is suggested. In general, the lesions effect seemed to depend on the strain predisposition to implement configural or cue-based responding. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)2485-2490
Number of pages6
Issue number11
Publication statusPublished - Aug 3 2000


  • Attention
  • Context
  • Inbred mice
  • Lesions
  • Nucleus accumbens
  • Radial arm maze

ASJC Scopus subject areas

  • Neuroscience(all)


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