Continued Decay of HIV Proviral DNA Upon Vaccination With HIV-1 Tat of Subjects on Long-Term ART: An 8-Year Follow-Up Study

Cecilia Sgadari, Paolo Monini, Antonella Tripiciano, Orietta Picconi, Anna Casabianca, Chiara Orlandi, Sonia Moretti, Vittorio Francavilla, Angela Arancio, Giovanni Paniccia, Massimo Campagna, Stefania Bellino, Marianna Meschiari, Silvia Nozza, Laura Sighinolfi, Alessandra Latini, Antonio Muscatello, Annalisa Saracino, Massimo Di Pietro, Massimo GalliAurelio Cafaro, Mauro Magnani, Fabrizio Ensoli, Barbara Ensoli

Research output: Contribution to journalArticle

Abstract

Introduction: Tat, a key HIV virulence protein, has been targeted for the development of a therapeutic vaccine aimed at cART intensification. Results from phase II clinical trials in Italy (ISS T-002) and South Africa (ISS T-003) indicated that Tat vaccination promotes increases of CD4(+) T-cells and return to immune homeostasis while reducing the virus reservoir in chronically cART-treated patients. Here we present data of 92 vaccinees (59 enrolled in the ISS T-002 8-year extended follow-up study (ISS T-002 EF-UP, ClinicalTrials. gov NCT02118168). Results: Anti-Tat antibodies (Abs) induced upon vaccination persisted for the entire follow-up in 34/92 (37 vaccinees, particularly when all 3 Ab classes (A/G/M) were present (66, as most frequently observed with Tat 30 mu g regimens. CD4+T cells increased above study-entry levels reaching a stable plateau at year 5 post-vaccination, with the highest increase (165 cells/mu L) in the Tat 30 mu g, 3x regimen. CD4(+)T-cell increase occurred even in subjects with CD4(+)nadir
Original languageEnglish
JournalFront. Immunol.
Volume10
DOIs
Publication statusPublished - Feb 13 2019

Keywords

  • HIV therapeutic vaccine
  • Tat
  • cART
  • anti-Tat antibodies
  • CD4(+) T cells
  • CD4(+)/CD8(+) T-cell ratio
  • proviral DNA
  • HIV reservoirs

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