Abstract
Background: Allergic reaction is characterized by a complex inflammatory process. Some of the new antihistamines have antiallergic effects and can affect the inflammatory cell recruitment via adhesion molecule downregulation. We aimed to assess in a 12-month study whether continuous treatment with an antihistamine (terrenadine) can reduce respiratory symptoms and local inflammation in children with mite allergy. Methods: The study was double-blind and placebo-controlled: it involved two parallel groups of children suffering from rhinoconjunctivitis and/or mild intermittent asthma due to mite allergy. They received either terfenadine (1 mg/kg per body weight per day) or placebo for 1 year. Nasal, conjunctival, and bronchial symptoms were recorded by diary cards; at each of the programmed control visits, a nasal scraping for inflammatory cells and ICAM-1 was performed. Some additional clinical parameters were also recorded: days of school absence, extra visits for acute respiratory symptoms, and days of hospital admission. Results: Only children treated with terfenadine achieved significant control of symptoms (P
| Original language | English |
|---|---|
| Pages (from-to) | 358-365 |
| Number of pages | 8 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Adhesion molecules
- Allergic inflammation
- Antihistamines
- Long-term treatment
- Mite allergy
ASJC Scopus subject areas
- Immunology
Cite this
Continuous antihistamine treatment controls allergic inflammation and reduces respiratory morbidity in children with mite allergy. / Ciprandi, G.; Tosca, M.; Ricca, V.; Passalacqua, G.; Canonica, G. W.; Landi, M.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 54, No. 4, 1999, p. 358-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Continuous antihistamine treatment controls allergic inflammation and reduces respiratory morbidity in children with mite allergy
AU - Ciprandi, G.
AU - Tosca, M.
AU - Ricca, V.
AU - Passalacqua, G.
AU - Canonica, G. W.
AU - Landi, M.
PY - 1999
Y1 - 1999
N2 - Background: Allergic reaction is characterized by a complex inflammatory process. Some of the new antihistamines have antiallergic effects and can affect the inflammatory cell recruitment via adhesion molecule downregulation. We aimed to assess in a 12-month study whether continuous treatment with an antihistamine (terrenadine) can reduce respiratory symptoms and local inflammation in children with mite allergy. Methods: The study was double-blind and placebo-controlled: it involved two parallel groups of children suffering from rhinoconjunctivitis and/or mild intermittent asthma due to mite allergy. They received either terfenadine (1 mg/kg per body weight per day) or placebo for 1 year. Nasal, conjunctival, and bronchial symptoms were recorded by diary cards; at each of the programmed control visits, a nasal scraping for inflammatory cells and ICAM-1 was performed. Some additional clinical parameters were also recorded: days of school absence, extra visits for acute respiratory symptoms, and days of hospital admission. Results: Only children treated with terfenadine achieved significant control of symptoms (P
AB - Background: Allergic reaction is characterized by a complex inflammatory process. Some of the new antihistamines have antiallergic effects and can affect the inflammatory cell recruitment via adhesion molecule downregulation. We aimed to assess in a 12-month study whether continuous treatment with an antihistamine (terrenadine) can reduce respiratory symptoms and local inflammation in children with mite allergy. Methods: The study was double-blind and placebo-controlled: it involved two parallel groups of children suffering from rhinoconjunctivitis and/or mild intermittent asthma due to mite allergy. They received either terfenadine (1 mg/kg per body weight per day) or placebo for 1 year. Nasal, conjunctival, and bronchial symptoms were recorded by diary cards; at each of the programmed control visits, a nasal scraping for inflammatory cells and ICAM-1 was performed. Some additional clinical parameters were also recorded: days of school absence, extra visits for acute respiratory symptoms, and days of hospital admission. Results: Only children treated with terfenadine achieved significant control of symptoms (P
KW - Adhesion molecules
KW - Allergic inflammation
KW - Antihistamines
KW - Long-term treatment
KW - Mite allergy
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UR - http://www.scopus.com/inward/citedby.url?scp=0032898976&partnerID=8YFLogxK
U2 - 10.1034/j.1398-9995.1999.00920.x
DO - 10.1034/j.1398-9995.1999.00920.x
M3 - Article
C2 - 10371095
AN - SCOPUS:0032898976
VL - 54
SP - 358
EP - 365
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 4
ER -