Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG

Paolo Manganotti, Emanuela Formaggio, Anna Gasparini, Roberto Cerini, Luigi Giuseppe Bongiovanni, Silvia Francesca Storti, Roberto Pozzi Mucelli, Antonio Fiaschi, Mirko Avesani

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: To verify whether in patients with partial epilepsy and routine electroenecephalogram (EEG) showing focal interictal slow-wave discharges without spikes combined EEG-functional magnetic resonance imaging (fMRI) would localize the corresponding epileptogenic focus, thus providing reliable information on the epileptic source. Methods: Eight patients with partial epileptic seizures whose routine scalp EEG recordings on presentation showed focal interictal slow-wave activity underwent EEG-fMRI. EEG data were continuously recorded for 24 min (four concatenated sessions) from 18 scalp electrodes, while fMRI scans were simultaneously acquired with a 1.5-Tesla magnetic resonance imaging (MRI) scanner. After recording sessions and MRI artefact removal, EEG data were analyzed offline. We compared blood oxygen level-dependent (BOLD) signal changes on fMRI with EEG recordings obtained at rest and during activation (with and without focal interictal slow-wave discharges). Results: In all patients, when the EEG tracing showed the onset of focal slow-wave discharges on a few lateralized electrodes, BOLD-fMRI activation in the corresponding brain area significantly increased. We detected significant concordance between focal EEG interictal slow-wave discharges and focal BOLD activation on fMRI. In patients with lesional epilepsy, the epileptogenic area corresponded to the sites of increased focal BOLD signal. Conclusions: Even in patients with partial epilepsy whose standard EEGs show focal interictal slow-wave discharges without spikes, EEG-fMRI can visualize related focal BOLD activation thus providing useful information for pre-surgical planning.

Original languageEnglish
Pages (from-to)1089-1100
Number of pages12
JournalMagnetic Resonance Imaging
Volume26
Issue number8
DOIs
Publication statusPublished - Oct 2008

Fingerprint

epilepsy
Partial Epilepsy
magnetic resonance
Magnetic Resonance Imaging
Blood
blood
Oxygen
Chemical activation
activation
Magnetic resonance
oxygen
recording
Scalp
spikes
Epilepsy
Imaging techniques
Electrodes
seizures
Electroencephalography
electroencephalography

Keywords

  • BOLD
  • Coregistration
  • EEG
  • fMRI
  • Partial seizures
  • Symptomatic epilepsy

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Manganotti, P., Formaggio, E., Gasparini, A., Cerini, R., Bongiovanni, L. G., Storti, S. F., ... Avesani, M. (2008). Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG. Magnetic Resonance Imaging, 26(8), 1089-1100. https://doi.org/10.1016/j.mri.2008.02.023

Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG. / Manganotti, Paolo; Formaggio, Emanuela; Gasparini, Anna; Cerini, Roberto; Bongiovanni, Luigi Giuseppe; Storti, Silvia Francesca; Mucelli, Roberto Pozzi; Fiaschi, Antonio; Avesani, Mirko.

In: Magnetic Resonance Imaging, Vol. 26, No. 8, 10.2008, p. 1089-1100.

Research output: Contribution to journalArticle

Manganotti, P, Formaggio, E, Gasparini, A, Cerini, R, Bongiovanni, LG, Storti, SF, Mucelli, RP, Fiaschi, A & Avesani, M 2008, 'Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG', Magnetic Resonance Imaging, vol. 26, no. 8, pp. 1089-1100. https://doi.org/10.1016/j.mri.2008.02.023
Manganotti P, Formaggio E, Gasparini A, Cerini R, Bongiovanni LG, Storti SF et al. Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG. Magnetic Resonance Imaging. 2008 Oct;26(8):1089-1100. https://doi.org/10.1016/j.mri.2008.02.023
Manganotti, Paolo ; Formaggio, Emanuela ; Gasparini, Anna ; Cerini, Roberto ; Bongiovanni, Luigi Giuseppe ; Storti, Silvia Francesca ; Mucelli, Roberto Pozzi ; Fiaschi, Antonio ; Avesani, Mirko. / Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG. In: Magnetic Resonance Imaging. 2008 ; Vol. 26, No. 8. pp. 1089-1100.
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