Abstract
Because of its favourable pharmacokinetic profile Levetiracetam (LEV) is an almost ideal anticonvulsant agent particularly for multi-morbid Intensive Care Unit (ICU)'s patients. Objective of this study is to evaluate LEV's effectiveness in patients with Status Epilepticus (SE) undergoing continuous EEG monitoring. 15 pts admitted in our Hospital ICUs with SE (5 NonConvulsive SE - NCSE - and 10 Convulsive SE - CSE) undergoing Continuous EEG monitoring during treatment with LEV (titration dose from 1500 to 4500 mg/die) are included. We administrated LEV as first drug in 13 of 15 pts. 2 pts of this group showed electroclinical SE suppression. In 5 pts clinical features was abolished, but an epileptic continuous EEG pattern persisted. 2 cases with refractory SE was also unresponsives to LEV. We observed that LEV shows a partial efficacy in these hard-management cases. Our experience enphatizes the role of continuous EEG monitoring, that depicts an essential tool particulary to detect the persistence of subclinical epileptic activity despite the disappearance of any clinical feature after AEDs administration.
| Original language | Italian |
|---|---|
| Pages (from-to) | 188-190 |
| Number of pages | 3 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 140 |
| Publication status | Published - Apr 2010 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Valutazione dell'efficacia del levetiracetam nello stato epilettico in pazienti sottoposti a monitoraggio EEG continuo. / Pulitano, P.; Randi, F.; Nardella, A.; Pro, S.; Mecarelli, O.
In: Bollettino - Lega Italiana contro l'Epilessia, No. 140, 04.2010, p. 188-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Valutazione dell'efficacia del levetiracetam nello stato epilettico in pazienti sottoposti a monitoraggio EEG continuo
AU - Pulitano, P.
AU - Randi, F.
AU - Nardella, A.
AU - Pro, S.
AU - Mecarelli, O.
PY - 2010/4
Y1 - 2010/4
N2 - Because of its favourable pharmacokinetic profile Levetiracetam (LEV) is an almost ideal anticonvulsant agent particularly for multi-morbid Intensive Care Unit (ICU)'s patients. Objective of this study is to evaluate LEV's effectiveness in patients with Status Epilepticus (SE) undergoing continuous EEG monitoring. 15 pts admitted in our Hospital ICUs with SE (5 NonConvulsive SE - NCSE - and 10 Convulsive SE - CSE) undergoing Continuous EEG monitoring during treatment with LEV (titration dose from 1500 to 4500 mg/die) are included. We administrated LEV as first drug in 13 of 15 pts. 2 pts of this group showed electroclinical SE suppression. In 5 pts clinical features was abolished, but an epileptic continuous EEG pattern persisted. 2 cases with refractory SE was also unresponsives to LEV. We observed that LEV shows a partial efficacy in these hard-management cases. Our experience enphatizes the role of continuous EEG monitoring, that depicts an essential tool particulary to detect the persistence of subclinical epileptic activity despite the disappearance of any clinical feature after AEDs administration.
AB - Because of its favourable pharmacokinetic profile Levetiracetam (LEV) is an almost ideal anticonvulsant agent particularly for multi-morbid Intensive Care Unit (ICU)'s patients. Objective of this study is to evaluate LEV's effectiveness in patients with Status Epilepticus (SE) undergoing continuous EEG monitoring. 15 pts admitted in our Hospital ICUs with SE (5 NonConvulsive SE - NCSE - and 10 Convulsive SE - CSE) undergoing Continuous EEG monitoring during treatment with LEV (titration dose from 1500 to 4500 mg/die) are included. We administrated LEV as first drug in 13 of 15 pts. 2 pts of this group showed electroclinical SE suppression. In 5 pts clinical features was abolished, but an epileptic continuous EEG pattern persisted. 2 cases with refractory SE was also unresponsives to LEV. We observed that LEV shows a partial efficacy in these hard-management cases. Our experience enphatizes the role of continuous EEG monitoring, that depicts an essential tool particulary to detect the persistence of subclinical epileptic activity despite the disappearance of any clinical feature after AEDs administration.
KW - Continuous EEG
KW - Levetiracetam
KW - Status epilepticus
UR - http://www.scopus.com/inward/record.url?scp=77953100343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953100343&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:77953100343
SP - 188
EP - 190
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 140
ER -