TY - JOUR
T1 - Continuous evidence of fast HIV disease progression related to class-wide resistance to antiretroviral drugs
T2 - A 6 year follow-up analysis of a large observational database
AU - Mauro, Zaccarelli
AU - Federica, Forbici
AU - Patrizia, Lorenzini
AU - Francesca, Ceccherini Silberstein
AU - Valerio, Tozzi
AU - Paola, Trotta Maria
AU - Patrizia, Marconi
AU - Pasquale, Narciso
AU - Federico, Perno Carlo
AU - Andrea, Antinori
PY - 2007/8
Y1 - 2007/8
N2 - Class-wide resistance (CWR) was increasingly associated with a higher risk of HIV progression after 72 months of follow-up among 1392 patients genotypic-tested after failure (AIDS risk 13% for no CWR to 34% for three CWR; AIDS/death risk 21-54%). At multivariate analysis, the detection of two and three CWR was significantly associated with a two and threefold increased risk, respectively, of death and AIDS/death, suggesting that extended resistance is a marker of disease progression in long-term observation.
AB - Class-wide resistance (CWR) was increasingly associated with a higher risk of HIV progression after 72 months of follow-up among 1392 patients genotypic-tested after failure (AIDS risk 13% for no CWR to 34% for three CWR; AIDS/death risk 21-54%). At multivariate analysis, the detection of two and three CWR was significantly associated with a two and threefold increased risk, respectively, of death and AIDS/death, suggesting that extended resistance is a marker of disease progression in long-term observation.
UR - http://www.scopus.com/inward/record.url?scp=34547737586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547737586&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e328273bbf5
DO - 10.1097/QAD.0b013e328273bbf5
M3 - Article
C2 - 17690586
AN - SCOPUS:34547737586
VL - 21
SP - 1824
EP - 1826
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 13
ER -