Continuous evidence of fast HIV disease progression related to class-wide resistance to antiretroviral drugs: A 6 year follow-up analysis of a large observational database

Zaccarelli Mauro, Forbici Federica, Lorenzini Patrizia, Ceccherini Silberstein Francesca, Tozzi Valerio, Trotta Maria Paola, Marconi Patrizia, Narciso Pasquale, Perno Carlo Federico, Antinori Andrea

Research output: Contribution to journalArticlepeer-review

Abstract

Class-wide resistance (CWR) was increasingly associated with a higher risk of HIV progression after 72 months of follow-up among 1392 patients genotypic-tested after failure (AIDS risk 13% for no CWR to 34% for three CWR; AIDS/death risk 21-54%). At multivariate analysis, the detection of two and three CWR was significantly associated with a two and threefold increased risk, respectively, of death and AIDS/death, suggesting that extended resistance is a marker of disease progression in long-term observation.

Original languageEnglish
Pages (from-to)1824-1826
Number of pages3
JournalAIDS (London, England)
Volume21
Issue number13
DOIs
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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