5-FLUORO-2 DEOSSI-URIDINA (FUDR) IN INFUSIONE CONTINUA CON RITMI CRONOBIOLOGICI CIRCADIANI NEI TUMORI DEL RENE METASTATICI E LOCALMENTE AVANZATI (N+ E/O V+)

Translated title of the contribution: Continuous infusion of 5-fluoro-2-deoxy-uridine (FUDR) with circadian chronobiologic rhythm in locally advanced metastatic renal tumor (N+ e/o V+)

G. Conti, S. Cappoli, E. Gianneo, G. C. Comeri, L. Frigerio, A. Marchiano, B. Damascelli

Research output: Contribution to journalArticlepeer-review

Abstract

Circadian continuous venous infusion of 5-fluoro-2-deoxy-uridine (PUDR) has been used to treat 134 metastatic renal cell carcinomas (RCC) and 14 locally advanced BCC (all N+). All patients underwent radical nephrectomy and did not receive previous chemo- or radiation therapy. The drug was delivered by the Medtronic Synchromed implantable system with the Hrushesky circadian chronobiologic pattern (14-day cycles of CHT alternating with 14-day intervals of heparinized physiologic saline infusion). The minimum follow-up was 6 months, with a range of 6-48 months and a median of 24 months. The range of treatment was between 3 and 36 months. Results showed 58 progressions (43.2%), 11 mixed responses (8.2%), 17 partial responses (12.7%), 8 complete responses (6%) and 40 stable disease (29.9%). The survival rate is about 40% at 1 year and 18% at 2 years. No toxicity was observed in 112 patients (83.6%), mild in 22 patients (16.4%) and severe (lung fibrosis) in 2 patients (1.5%). In the group of locally advanced RCC all patients are disease-free at a mean follow-up of 15 months (range 6-24 months).

Translated title of the contributionContinuous infusion of 5-fluoro-2-deoxy-uridine (FUDR) with circadian chronobiologic rhythm in locally advanced metastatic renal tumor (N+ e/o V+)
Original languageItalian
Pages (from-to)165-167
Number of pages3
JournalActa Urologica Italica
Volume6
Issue numberSUPPL. 6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Urology

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