Continuous infusion versus bolus injection of furosemide in pediatric patients after cardiac surgery: A meta-analysis of randomized studies

Alberto Zangrillo, Luca Cabrini, Giuseppe G L Biondi-Zoccai, Giacomo Monti, Stefano Turi, Imad Sheiban, Elena Bignami, Giovanni Landoni

Research output: Contribution to journalArticle

Abstract

Introduction. Acute renal failure and fluid retention are common problems in pediatric patients after cardiac surgery. Furosemide, a loop diuretic drug, is frequently administered to increase urinary output. The aim of the present study was to compare efficacy and complications of continuous infusion of furosemide vs bolus injection among pediatric patients after cardiac surgery. Methods. A systematic review and meta-analysis was performed in compliance with The Cochrane Collaboration and the Quality of Reporting of Meta-Analysis (QUORUM) guidelines. The following inclusion criteria were employed for potentially relevant studies: a) random treatment allocation, b) comparison of furosemide bolus vs continuous infusion, c) surgical or intensive care pediatric patients. Non-parallel design randomized trials (e.g. cross-over), duplicate publications and non-human experimental studies were excluded. Results. Up to August 2008, only three studies were found, with 92 patients randomized (50 to continuous infusion and 42 to bolus treatment). Overall analysis showed that continuous infusion and bolus administration were equally effective in achieving the predefined urinary output, and were associated with a similar amount of administered furosemide (WMD=- 1.71 mg/kg/day [-5.20; +1.78], p for effect=0.34, p for heterogeneity

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalSigna Vitae
Volume7
Issue number1
Publication statusPublished - 2012

Keywords

  • Acute kidney failure
  • Cardiac surgery
  • Furosemide
  • Intensive care unit
  • Meta-analysis
  • Paediatric

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

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