Abstract
Long-term oral therapy with levodopa is associated with the development of motor fluctuations and dyskinesia in a large percentage of patients with Parkinson's disease (PD). Motor complications are associated with a number of non-motor symptoms and have a negative impact on disability and quality of life. There are three therapeutic options available for the management of patients at this advanced stage: high frequency deep brain stimulation, continuous subcutaneous infusion of apomorphine, and continuous intestinal infusion of levodopa/carbidopa. On the basis of published data and in consideration of the risk-benefit profile of current therapeutic strategies, we here propose an algorithm to help clinicians select the most suitable treatment option for patients with advanced PD.
Original language | English |
---|---|
Pages (from-to) | 147-154 |
Number of pages | 8 |
Journal | Functional Neurology |
Volume | 27 |
Issue number | 3 |
Publication status | Published - Jul 2012 |
Keywords
- Continuous dopaminergic stimulation
- Deep brain stimulation
- Levodopa/carbidopa intestinal gel infusion
- Parkinson's disease
- Patient selection
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)