Continuous positive airway pressure increases haemoglobin O2 saturation after acute but not prolonged altitude exposure

Piergiuseppe Agostoni, Gianluca Caldara, Maurizio Bussotti, Miriam Revera, Mariaconsuelo Valentini, Francesca Gregorini, Andrea Faini, Carolina Lombardi, Gregorz Bilo, Andrea Giuliano, Fabrizio Veglia, Giulio Savia, Pietro A. Modesti, Giuseppe Mancia, Gianfranco Parati

Research output: Contribution to journalArticlepeer-review

Abstract

AimsIt is unknown whether subclinical high-altitude pulmonary oedema reduces spontaneously after prolonged altitude exposure. Continuous positive airway pressure (CPAP) removes extravascular lung fluids and improves haemoglobin oxygen saturation in acute cardiogenic oedema. We evaluated the presence of pulmonary extravascular fluid increase by assessing CPAP effects on haemoglobin oxygen saturation under acute and prolonged altitude exposure.Methods and resultsWe applied 7 cm H2O CPAP for 30 min to healthy individuals after acute (Capanna Margherita, CM, 4559 m, 2 days permanence, and 2-sat increase suggesting a reduction in alveolar fluids.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalEuropean Heart Journal
Volume31
Issue number4
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Arterial blood oxygen saturation
  • High altitude pulmonary oedema
  • Hypobaric hypoxia at altitude
  • Positive pressure ventilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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