Contrast agents and temporal resolution in breast MR imaging

F. Sardanelli, A. Iozzelli, A. Fausto

Research output: Contribution to journalArticlepeer-review


The article summarizes the technique of dynamic Gd-enhanced breast magnetic resonance (MR) imaging and the established clinical indications to this examination. The main features of the four different non-selective Gd-chelates today available for contrast-enhanced MR breast imaging are described. Their typical two-compartment (vascular/interstitial) distribution is related to the temporal resolution used for the MR acquisition; the gain in specificity obtained increasing the temporal resolution during the first phase after the contrast intravenous injection (using both, rapid T1-weighted sequences or ultrafast T2*-weighted perfusion imaging) is discussed. Moreover, a survey of new contrast agents is supplied, including a high T1-relaxivity Gd-chelate, blood pool agents, and lymph node targeted agents. In conclusion, future directions are delineated.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Issue number3 SUPPL.
Publication statusPublished - Sep 2002


  • Breast
  • MR (Magnetic Resonance) Imaging
  • MR Contrast agents
  • MR temporal resolution

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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