Abstract
Rationale and Objectives: To predict the T stage of nonrectal colon cancer using contrast-enhanced computed tomography colonography. Materials and Methods: Sixty-one patients with 67 nonrectal colon cancers consecutively underwent contrast-enhanced computed tomography colonography after an incomplete colonoscopy. Two readers evaluated wall deformity and perilesional fat abnormality on three-dimensional double contrast enema-like views and multiplanar reconstructions. Pathology was used as the standard of reference. McNemar, Fisher, and Cohen κ statistics were used. Results: At pathologic examination, we found the following stages: T1 (n = 5), T2 (n = 10), T3 (n = 41), T4a (n = 6), and T4b (n = 5). Intraobserver and interobserver reproducibilities were almost perfect for wall deformity (κ = 1.00 and κ = 0.88, respectively), substantial for perilesional fat abnormality (κ = 0.79 and κ = 0.74, respectively). Using the results of the more experienced reader, accuracy of wall deformity ≥50% (apple-core) alone for T ≥ 3 was 62 of 67 (0.93, 95% confidence interval [CI] 0.83-0.97) and that of perilesional fat abnormality alone was 37 of 67 (0.55, 95% CI 0.43-0.67) (P <.001). Predictive value for ≥ T3 of the association wall deformity ≥50% with perilesional fat abnormality was 22 of 22 (1.00, 95% CI 0.85-1.00), higher, but not significantly, than that of wall deformity ≥50% with normal perilesional fat 29 of 33 (0.88, 95% CI 0.72-0.97) (P = .148, Fisher exact test). Conclusions: The presence of apple-core wall deformity, regardless of perilesional fat abnormality, is highly predictive of stage T3 or higher.
| Original language | English |
|---|---|
| Pages (from-to) | 590-595 |
| Number of pages | 6 |
| Journal | Academic Radiology |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2013 |
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Keywords
- Colon cancer
- Contrast-enhanced CT
- CT colonography
- T staging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Contrast-enhanced computed tomography colonography in preoperative distinction between T1-T2 and T3-T4 staging of colon cancer. / Flor, Nicola; Mezzanzanica, Miriam; Rigamonti, Paolo; Rocco, Elena Guerini; Bosari, Silvano; Ceretti, Andrea Pisani; Soldi, Simone; Peri, Mauro; Sardanelli, Francesco; Cornalba, Gian Paolo.
In: Academic Radiology, Vol. 20, No. 5, 05.2013, p. 590-595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contrast-enhanced computed tomography colonography in preoperative distinction between T1-T2 and T3-T4 staging of colon cancer
AU - Flor, Nicola
AU - Mezzanzanica, Miriam
AU - Rigamonti, Paolo
AU - Rocco, Elena Guerini
AU - Bosari, Silvano
AU - Ceretti, Andrea Pisani
AU - Soldi, Simone
AU - Peri, Mauro
AU - Sardanelli, Francesco
AU - Cornalba, Gian Paolo
PY - 2013/5
Y1 - 2013/5
N2 - Rationale and Objectives: To predict the T stage of nonrectal colon cancer using contrast-enhanced computed tomography colonography. Materials and Methods: Sixty-one patients with 67 nonrectal colon cancers consecutively underwent contrast-enhanced computed tomography colonography after an incomplete colonoscopy. Two readers evaluated wall deformity and perilesional fat abnormality on three-dimensional double contrast enema-like views and multiplanar reconstructions. Pathology was used as the standard of reference. McNemar, Fisher, and Cohen κ statistics were used. Results: At pathologic examination, we found the following stages: T1 (n = 5), T2 (n = 10), T3 (n = 41), T4a (n = 6), and T4b (n = 5). Intraobserver and interobserver reproducibilities were almost perfect for wall deformity (κ = 1.00 and κ = 0.88, respectively), substantial for perilesional fat abnormality (κ = 0.79 and κ = 0.74, respectively). Using the results of the more experienced reader, accuracy of wall deformity ≥50% (apple-core) alone for T ≥ 3 was 62 of 67 (0.93, 95% confidence interval [CI] 0.83-0.97) and that of perilesional fat abnormality alone was 37 of 67 (0.55, 95% CI 0.43-0.67) (P <.001). Predictive value for ≥ T3 of the association wall deformity ≥50% with perilesional fat abnormality was 22 of 22 (1.00, 95% CI 0.85-1.00), higher, but not significantly, than that of wall deformity ≥50% with normal perilesional fat 29 of 33 (0.88, 95% CI 0.72-0.97) (P = .148, Fisher exact test). Conclusions: The presence of apple-core wall deformity, regardless of perilesional fat abnormality, is highly predictive of stage T3 or higher.
AB - Rationale and Objectives: To predict the T stage of nonrectal colon cancer using contrast-enhanced computed tomography colonography. Materials and Methods: Sixty-one patients with 67 nonrectal colon cancers consecutively underwent contrast-enhanced computed tomography colonography after an incomplete colonoscopy. Two readers evaluated wall deformity and perilesional fat abnormality on three-dimensional double contrast enema-like views and multiplanar reconstructions. Pathology was used as the standard of reference. McNemar, Fisher, and Cohen κ statistics were used. Results: At pathologic examination, we found the following stages: T1 (n = 5), T2 (n = 10), T3 (n = 41), T4a (n = 6), and T4b (n = 5). Intraobserver and interobserver reproducibilities were almost perfect for wall deformity (κ = 1.00 and κ = 0.88, respectively), substantial for perilesional fat abnormality (κ = 0.79 and κ = 0.74, respectively). Using the results of the more experienced reader, accuracy of wall deformity ≥50% (apple-core) alone for T ≥ 3 was 62 of 67 (0.93, 95% confidence interval [CI] 0.83-0.97) and that of perilesional fat abnormality alone was 37 of 67 (0.55, 95% CI 0.43-0.67) (P <.001). Predictive value for ≥ T3 of the association wall deformity ≥50% with perilesional fat abnormality was 22 of 22 (1.00, 95% CI 0.85-1.00), higher, but not significantly, than that of wall deformity ≥50% with normal perilesional fat 29 of 33 (0.88, 95% CI 0.72-0.97) (P = .148, Fisher exact test). Conclusions: The presence of apple-core wall deformity, regardless of perilesional fat abnormality, is highly predictive of stage T3 or higher.
KW - Colon cancer
KW - Contrast-enhanced CT
KW - CT colonography
KW - T staging
UR - http://www.scopus.com/inward/record.url?scp=84875880968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875880968&partnerID=8YFLogxK
U2 - 10.1016/j.acra.2013.01.008
DO - 10.1016/j.acra.2013.01.008
M3 - Article
C2 - 23477825
AN - SCOPUS:84875880968
VL - 20
SP - 590
EP - 595
JO - Academic Radiology
JF - Academic Radiology
SN - 1076-6332
IS - 5
ER -