Contrast enhanced CT-scan to diagnose intrahepatic cholangiocarcinoma in patients with cirrhosis

Massimo Iavarone, Fabio Piscaglia, Sara Vavassori, Marzia Galassi, Angelo Sangiovanni, Laura Venerandi, Laura Virginia Forzenigo, Rita Golfieri, Luigi Bolondi, Massimo Colombo

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Background & Aims: Contrast enhanced computed tomography (CT-scan) is a standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. This technique, however, is not validated to exclude intrahepatic cholangiocarcinoma (ICC) which may develop in patients with cirrhosis, as well. Methods: To assess the features of contrast CT-scan in the diagnosis of ICC, we reviewed all CT-scan films obtained in cirrhotic patients with a histologically documented ICC, taking in consideration the pattern and dynamics of the arterial, portal venous and delayed phases of contrast uptake. Results: Thirty-two patients had 40 nodules of ICC (22 male; median age 62 years; 13 hepatitis C) that were identified either during surveillance with abdominal ultrasound (21 patients, 66%) or incidentally (11 patients, 34%). ICC was either multifocal or ≥30 mm in 11 of the former and 10 of the latter group (52% vs. 91%, p

Original languageEnglish
Pages (from-to)1188-1193
Number of pages6
JournalJournal of Hepatology
Issue number6
Publication statusPublished - Jun 2013


  • Cholangiocarcinoma
  • Cirrhosis
  • CT-scan
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)


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