TY - JOUR
T1 - Contrast enhanced CT-scan to diagnose intrahepatic cholangiocarcinoma in patients with cirrhosis
AU - Iavarone, Massimo
AU - Piscaglia, Fabio
AU - Vavassori, Sara
AU - Galassi, Marzia
AU - Sangiovanni, Angelo
AU - Venerandi, Laura
AU - Forzenigo, Laura Virginia
AU - Golfieri, Rita
AU - Bolondi, Luigi
AU - Colombo, Massimo
PY - 2013/6
Y1 - 2013/6
N2 - Background & Aims: Contrast enhanced computed tomography (CT-scan) is a standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. This technique, however, is not validated to exclude intrahepatic cholangiocarcinoma (ICC) which may develop in patients with cirrhosis, as well. Methods: To assess the features of contrast CT-scan in the diagnosis of ICC, we reviewed all CT-scan films obtained in cirrhotic patients with a histologically documented ICC, taking in consideration the pattern and dynamics of the arterial, portal venous and delayed phases of contrast uptake. Results: Thirty-two patients had 40 nodules of ICC (22 male; median age 62 years; 13 hepatitis C) that were identified either during surveillance with abdominal ultrasound (21 patients, 66%) or incidentally (11 patients, 34%). ICC was either multifocal or ≥30 mm in 11 of the former and 10 of the latter group (52% vs. 91%, p
AB - Background & Aims: Contrast enhanced computed tomography (CT-scan) is a standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. This technique, however, is not validated to exclude intrahepatic cholangiocarcinoma (ICC) which may develop in patients with cirrhosis, as well. Methods: To assess the features of contrast CT-scan in the diagnosis of ICC, we reviewed all CT-scan films obtained in cirrhotic patients with a histologically documented ICC, taking in consideration the pattern and dynamics of the arterial, portal venous and delayed phases of contrast uptake. Results: Thirty-two patients had 40 nodules of ICC (22 male; median age 62 years; 13 hepatitis C) that were identified either during surveillance with abdominal ultrasound (21 patients, 66%) or incidentally (11 patients, 34%). ICC was either multifocal or ≥30 mm in 11 of the former and 10 of the latter group (52% vs. 91%, p
KW - Cholangiocarcinoma
KW - Cirrhosis
KW - CT-scan
KW - Hepatocellular carcinoma
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U2 - 10.1016/j.jhep.2013.02.013
DO - 10.1016/j.jhep.2013.02.013
M3 - Article
C2 - 23485522
AN - SCOPUS:84877921432
VL - 58
SP - 1188
EP - 1193
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 6
ER -