Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases

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Abstract

Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29% of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.

Original languageEnglish
Pages (from-to)1148-1154
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume9
Issue number8
DOIs
Publication statusPublished - Nov 1 2005

Fingerprint

Hepatectomy
Liver Neoplasms
Colorectal Neoplasms
Ultrasonography
Neoplasm Metastasis
Sulfur Hexafluoride
Microbubbles
Liver
Intravenous Injections
Neoplasms

Keywords

  • Contrast-enhanced ultrasound
  • Intraoperative ultrasonography
  • Laparoscopic ultrasonography
  • Liver metastases
  • Liver tumors, diagnosis
  • Liver tumors, staging
  • Liver tumors, surgery

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases",
abstract = "Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29{\%} of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.",
keywords = "Contrast-enhanced ultrasound, Intraoperative ultrasonography, Laparoscopic ultrasonography, Liver metastases, Liver tumors, diagnosis, Liver tumors, staging, Liver tumors, surgery",
author = "Guido Torzilli and {Del Fabbro}, Daniele and Angela Palmisano and Matteo Donadon and Paolo Bianchi and Massimo Roncalli and Luca Balzarini and Marco Montorsi",
year = "2005",
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T1 - Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases

AU - Torzilli, Guido

AU - Del Fabbro, Daniele

AU - Palmisano, Angela

AU - Donadon, Matteo

AU - Bianchi, Paolo

AU - Roncalli, Massimo

AU - Balzarini, Luca

AU - Montorsi, Marco

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29% of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.

AB - Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29% of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.

KW - Contrast-enhanced ultrasound

KW - Intraoperative ultrasonography

KW - Laparoscopic ultrasonography

KW - Liver metastases

KW - Liver tumors, diagnosis

KW - Liver tumors, staging

KW - Liver tumors, surgery

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