Abstract
Purpose: This study evaluated the effectiveness of contrast-enhanced ultrasound (CEUS), performed immediately after percutaneous ethanol injection (PEI) or radiofrequency thermal ablation (RFTA), by comparing results with the computed tomography (CT) follow-up. Materials and methods: Sixty-nine consecutive patients with a diagnosis of hepatocellular carcinoma (HCC) were included in this prospective study. All patients underwent PEI or RFTA. After treatment, three CEUS enhancement patterns were observed: isovascular, hypovascular and avascular, which were compared with the CT findings. Sensitivity of the avascular pattern at CEUS and effectiveness of the ablative procedures were evaluated and compared with the chi-square test. Results: Ninety hypervascular HCCs, with a mean diameter of 2.6 cm (0.5-4.9 cm), underwent PEI (n=54) and RFTA (n=36). In the first group, CT identified complete necrosis in 28/54 (52%) lesions, 21 (75%) of which had avascular, one (4%) isovascular and six (21%) hypovascular patterns at CEUS. In the second group, CT showed complete necrosis in 31/36 (86%) lesions, all (100%) of which had a corresponding avascular pattern at CEUS. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the avascular pattern at CEUS compared with CT findings were 75%, 69%, 72%, 72% and 72% for PEI and 100%, 20%, 89%, 100% and 89%, for RFTA, respectively. A statistically significant difference (p
| Original language | Italian |
|---|---|
| Pages (from-to) | 1094-1105 |
| Number of pages | 12 |
| Journal | Radiologia Medica |
| Volume | 114 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 2009 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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Ecografia con mezzo di contrasto (CEUS) immediatamente dopo ablazione percutanea dell'epatocarcinoma. / Gallotti, A.; D'Onofrio, M.; Ruzzenente, A.; Martone, E.; De Robertis, R.; Guglielmi, A.; Pozzi Mucelli, R.
In: Radiologia Medica, Vol. 114, No. 7, 10.2009, p. 1094-1105.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ecografia con mezzo di contrasto (CEUS) immediatamente dopo ablazione percutanea dell'epatocarcinoma
AU - Gallotti, A.
AU - D'Onofrio, M.
AU - Ruzzenente, A.
AU - Martone, E.
AU - De Robertis, R.
AU - Guglielmi, A.
AU - Pozzi Mucelli, R.
PY - 2009/10
Y1 - 2009/10
N2 - Purpose: This study evaluated the effectiveness of contrast-enhanced ultrasound (CEUS), performed immediately after percutaneous ethanol injection (PEI) or radiofrequency thermal ablation (RFTA), by comparing results with the computed tomography (CT) follow-up. Materials and methods: Sixty-nine consecutive patients with a diagnosis of hepatocellular carcinoma (HCC) were included in this prospective study. All patients underwent PEI or RFTA. After treatment, three CEUS enhancement patterns were observed: isovascular, hypovascular and avascular, which were compared with the CT findings. Sensitivity of the avascular pattern at CEUS and effectiveness of the ablative procedures were evaluated and compared with the chi-square test. Results: Ninety hypervascular HCCs, with a mean diameter of 2.6 cm (0.5-4.9 cm), underwent PEI (n=54) and RFTA (n=36). In the first group, CT identified complete necrosis in 28/54 (52%) lesions, 21 (75%) of which had avascular, one (4%) isovascular and six (21%) hypovascular patterns at CEUS. In the second group, CT showed complete necrosis in 31/36 (86%) lesions, all (100%) of which had a corresponding avascular pattern at CEUS. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the avascular pattern at CEUS compared with CT findings were 75%, 69%, 72%, 72% and 72% for PEI and 100%, 20%, 89%, 100% and 89%, for RFTA, respectively. A statistically significant difference (p
AB - Purpose: This study evaluated the effectiveness of contrast-enhanced ultrasound (CEUS), performed immediately after percutaneous ethanol injection (PEI) or radiofrequency thermal ablation (RFTA), by comparing results with the computed tomography (CT) follow-up. Materials and methods: Sixty-nine consecutive patients with a diagnosis of hepatocellular carcinoma (HCC) were included in this prospective study. All patients underwent PEI or RFTA. After treatment, three CEUS enhancement patterns were observed: isovascular, hypovascular and avascular, which were compared with the CT findings. Sensitivity of the avascular pattern at CEUS and effectiveness of the ablative procedures were evaluated and compared with the chi-square test. Results: Ninety hypervascular HCCs, with a mean diameter of 2.6 cm (0.5-4.9 cm), underwent PEI (n=54) and RFTA (n=36). In the first group, CT identified complete necrosis in 28/54 (52%) lesions, 21 (75%) of which had avascular, one (4%) isovascular and six (21%) hypovascular patterns at CEUS. In the second group, CT showed complete necrosis in 31/36 (86%) lesions, all (100%) of which had a corresponding avascular pattern at CEUS. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the avascular pattern at CEUS compared with CT findings were 75%, 69%, 72%, 72% and 72% for PEI and 100%, 20%, 89%, 100% and 89%, for RFTA, respectively. A statistically significant difference (p
KW - Ablation therapy
KW - Computed tomography
KW - Contrast-enhanced ultrasound
KW - Ethanol injection
KW - Hepatocellular carcinoma
KW - Radiofrequency
UR - http://www.scopus.com/inward/record.url?scp=70450171114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70450171114&partnerID=8YFLogxK
U2 - 10.1007/s11547-009-0436-0
DO - 10.1007/s11547-009-0436-0
M3 - Articolo
C2 - 19756947
AN - SCOPUS:70450171114
VL - 114
SP - 1094
EP - 1105
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 7
ER -