Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions: A preliminary study

Marco Sperandeo, Giuseppe Sperandeo, Antonio Varriale, Paola Filabozzi, Marco Decuzzi, Lucia Dimitri, Gianluigi Vendemiale

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The use of contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions has never been systematically investigated. We evaluated the CEUS patterns of 98 peripheral lung lesions before performing US-guided fine-needle biopsies (FNB). The examinations were done with an Esaote Technos MPX scanner in the harmonic mode with a mechanical index of 0.04 or less. Contrast enhancement was achieved with a 4.8 mL bolus of SonoVue (Bracco) administered via an antecubital vein. All FNBs performed under CEUS guidance were adequate for pathologic diagnosis. Seventy-eight lesions were malignant: 33 (41.9%) were adenocarcinomas, 29 (36.5%) were squamous-cell carcinomas, 13 (17.6%) were undifferentiated large-cell carcinomas and the remaining three (4.1%) were small-cell carcinomas. All presented intralesional enhancement consistent with tumor neovascularization. In some cases, there were unenhanced areas consistent with zones of necrosis and these areas were avoided during FNB. The other 20 lesions were benign (four lipomas, two fibrous lung tumor, two noncaseous granulomas, six abscesses, one rheumatoid nodule, one histiocytosis X, one chondroid hamartoma, one sclerosing hemangioma, two sarcoid nodules) and none presented intralesional enhancement. This initial and admittedly limited experience suggests that CEUS may provide diagnostically useful information on peripheral lung lesions and increase the diagnostic yield of transthoracic FNB by reducing the risk of inadequate tissue sampling. (E-mail: sperandeom@libero.it).

Original languageEnglish
Pages (from-to)1467-1472
Number of pages6
JournalUltrasound in Medicine and Biology
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 2006

Fingerprint

lungs
lesions
Fine Needle Biopsy
Lung
needles
cancer
nodules
Rheumatoid Nodule
augmentation
Benign Fibrous Histiocytoma
Large Cell Carcinoma
tumors
Langerhans Cell Histiocytosis
Small Cell Carcinoma
Hamartoma
Lipoma
angiogenesis
Granuloma
Abscess
necrosis

Keywords

  • Contrast-enhanced ultrasonography
  • Lung tumors
  • Transthoracic fine-needle biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions : A preliminary study. / Sperandeo, Marco; Sperandeo, Giuseppe; Varriale, Antonio; Filabozzi, Paola; Decuzzi, Marco; Dimitri, Lucia; Vendemiale, Gianluigi.

In: Ultrasound in Medicine and Biology, Vol. 32, No. 10, 10.2006, p. 1467-1472.

Research output: Contribution to journalArticle

Sperandeo, Marco ; Sperandeo, Giuseppe ; Varriale, Antonio ; Filabozzi, Paola ; Decuzzi, Marco ; Dimitri, Lucia ; Vendemiale, Gianluigi. / Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions : A preliminary study. In: Ultrasound in Medicine and Biology. 2006 ; Vol. 32, No. 10. pp. 1467-1472.
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