Abstract
The use of contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions has never been systematically investigated. We evaluated the CEUS patterns of 98 peripheral lung lesions before performing US-guided fine-needle biopsies (FNB). The examinations were done with an Esaote Technos MPX scanner in the harmonic mode with a mechanical index of 0.04 or less. Contrast enhancement was achieved with a 4.8 mL bolus of SonoVue (Bracco) administered via an antecubital vein. All FNBs performed under CEUS guidance were adequate for pathologic diagnosis. Seventy-eight lesions were malignant: 33 (41.9%) were adenocarcinomas, 29 (36.5%) were squamous-cell carcinomas, 13 (17.6%) were undifferentiated large-cell carcinomas and the remaining three (4.1%) were small-cell carcinomas. All presented intralesional enhancement consistent with tumor neovascularization. In some cases, there were unenhanced areas consistent with zones of necrosis and these areas were avoided during FNB. The other 20 lesions were benign (four lipomas, two fibrous lung tumor, two noncaseous granulomas, six abscesses, one rheumatoid nodule, one histiocytosis X, one chondroid hamartoma, one sclerosing hemangioma, two sarcoid nodules) and none presented intralesional enhancement. This initial and admittedly limited experience suggests that CEUS may provide diagnostically useful information on peripheral lung lesions and increase the diagnostic yield of transthoracic FNB by reducing the risk of inadequate tissue sampling. (E-mail: sperandeom@libero.it).
| Original language | English |
|---|---|
| Pages (from-to) | 1467-1472 |
| Number of pages | 6 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2006 |
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Keywords
- Contrast-enhanced ultrasonography
- Lung tumors
- Transthoracic fine-needle biopsy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions : A preliminary study. / Sperandeo, Marco; Sperandeo, Giuseppe; Varriale, Antonio; Filabozzi, Paola; Decuzzi, Marco; Dimitri, Lucia; Vendemiale, Gianluigi.
In: Ultrasound in Medicine and Biology, Vol. 32, No. 10, 10.2006, p. 1467-1472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions
T2 - A preliminary study
AU - Sperandeo, Marco
AU - Sperandeo, Giuseppe
AU - Varriale, Antonio
AU - Filabozzi, Paola
AU - Decuzzi, Marco
AU - Dimitri, Lucia
AU - Vendemiale, Gianluigi
PY - 2006/10
Y1 - 2006/10
N2 - The use of contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions has never been systematically investigated. We evaluated the CEUS patterns of 98 peripheral lung lesions before performing US-guided fine-needle biopsies (FNB). The examinations were done with an Esaote Technos MPX scanner in the harmonic mode with a mechanical index of 0.04 or less. Contrast enhancement was achieved with a 4.8 mL bolus of SonoVue (Bracco) administered via an antecubital vein. All FNBs performed under CEUS guidance were adequate for pathologic diagnosis. Seventy-eight lesions were malignant: 33 (41.9%) were adenocarcinomas, 29 (36.5%) were squamous-cell carcinomas, 13 (17.6%) were undifferentiated large-cell carcinomas and the remaining three (4.1%) were small-cell carcinomas. All presented intralesional enhancement consistent with tumor neovascularization. In some cases, there were unenhanced areas consistent with zones of necrosis and these areas were avoided during FNB. The other 20 lesions were benign (four lipomas, two fibrous lung tumor, two noncaseous granulomas, six abscesses, one rheumatoid nodule, one histiocytosis X, one chondroid hamartoma, one sclerosing hemangioma, two sarcoid nodules) and none presented intralesional enhancement. This initial and admittedly limited experience suggests that CEUS may provide diagnostically useful information on peripheral lung lesions and increase the diagnostic yield of transthoracic FNB by reducing the risk of inadequate tissue sampling. (E-mail: sperandeom@libero.it).
AB - The use of contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions has never been systematically investigated. We evaluated the CEUS patterns of 98 peripheral lung lesions before performing US-guided fine-needle biopsies (FNB). The examinations were done with an Esaote Technos MPX scanner in the harmonic mode with a mechanical index of 0.04 or less. Contrast enhancement was achieved with a 4.8 mL bolus of SonoVue (Bracco) administered via an antecubital vein. All FNBs performed under CEUS guidance were adequate for pathologic diagnosis. Seventy-eight lesions were malignant: 33 (41.9%) were adenocarcinomas, 29 (36.5%) were squamous-cell carcinomas, 13 (17.6%) were undifferentiated large-cell carcinomas and the remaining three (4.1%) were small-cell carcinomas. All presented intralesional enhancement consistent with tumor neovascularization. In some cases, there were unenhanced areas consistent with zones of necrosis and these areas were avoided during FNB. The other 20 lesions were benign (four lipomas, two fibrous lung tumor, two noncaseous granulomas, six abscesses, one rheumatoid nodule, one histiocytosis X, one chondroid hamartoma, one sclerosing hemangioma, two sarcoid nodules) and none presented intralesional enhancement. This initial and admittedly limited experience suggests that CEUS may provide diagnostically useful information on peripheral lung lesions and increase the diagnostic yield of transthoracic FNB by reducing the risk of inadequate tissue sampling. (E-mail: sperandeom@libero.it).
KW - Contrast-enhanced ultrasonography
KW - Lung tumors
KW - Transthoracic fine-needle biopsy
UR - http://www.scopus.com/inward/record.url?scp=33749669778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749669778&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2006.06.018
DO - 10.1016/j.ultrasmedbio.2006.06.018
M3 - Article
C2 - 17045865
AN - SCOPUS:33749669778
VL - 32
SP - 1467
EP - 1472
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 10
ER -