Contrast enhanced ultrasound in atherosclerotic carotid artery disease

G. Varetto, L. Gibello, L. Bergamasco, A. Sapino, I. Castellano, P. Garneri, P. Rispoli

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim. The traditional morphological parameters for the description of a carotid atherosclerotic plaque (degree of stenosis, echogenicity, systolic peak velocity etc.) are insufficient for the prediction of the risk of embolization. Contrast enhanced ultrasound (CEUS), based on the theory of inflammation and neoangiogenesis, seems to have a great potential for the detection of unstable plaques. The purpose of our work was to compare echogenicity of the plaque (evaluated with the Grey Scale Median; GSM), the degree of stenosis and CEUS with the histopathological findings. Methods. Patients with indication for internal carotid endarterectomy (CEA) underwent a preoperative imaging study with B-mode echo Doppler Ultrasound and with CEUS. The contrast enhancement of the plaque was described with two parameters: the maximum and mean signal intensity (SImax, SImean). After the surgical operation the removed plaque is sent to the pathology laboratory for the measurement of the neoangiogenesis (vessel density, VD). Results. Fifty-one consecutive patients were enrolled (12 symptomatic, 39 asymptomatic). Analysis pointed out significant differences between symptomatic and asymptomatic patients fon GSM median 14 (I quartile 11.5; III quartile 23) versus 32.5 (27-42.25) (P=0.012); SI (%) SImax 30 (29-35.5) versus 24 (19.7-27) (P

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalInternational Angiology
Volume31
Issue number6
Publication statusPublished - Dec 2012

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Carotid Artery Diseases
Pathologic Constriction
Doppler Ultrasonography
Carotid Endarterectomy
Atherosclerotic Plaques
Pathology
Inflammation

Keywords

  • Carotid stenosis
  • Plaque, atherosclerotic
  • Stroke
  • Ultrasonography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Varetto, G., Gibello, L., Bergamasco, L., Sapino, A., Castellano, I., Garneri, P., & Rispoli, P. (2012). Contrast enhanced ultrasound in atherosclerotic carotid artery disease. International Angiology, 31(6), 565-571.

Contrast enhanced ultrasound in atherosclerotic carotid artery disease. / Varetto, G.; Gibello, L.; Bergamasco, L.; Sapino, A.; Castellano, I.; Garneri, P.; Rispoli, P.

In: International Angiology, Vol. 31, No. 6, 12.2012, p. 565-571.

Research output: Contribution to journalArticle

Varetto, G, Gibello, L, Bergamasco, L, Sapino, A, Castellano, I, Garneri, P & Rispoli, P 2012, 'Contrast enhanced ultrasound in atherosclerotic carotid artery disease', International Angiology, vol. 31, no. 6, pp. 565-571.
Varetto G, Gibello L, Bergamasco L, Sapino A, Castellano I, Garneri P et al. Contrast enhanced ultrasound in atherosclerotic carotid artery disease. International Angiology. 2012 Dec;31(6):565-571.
Varetto, G. ; Gibello, L. ; Bergamasco, L. ; Sapino, A. ; Castellano, I. ; Garneri, P. ; Rispoli, P. / Contrast enhanced ultrasound in atherosclerotic carotid artery disease. In: International Angiology. 2012 ; Vol. 31, No. 6. pp. 565-571.
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