Contrast-enhanced Ultrasound: Past, Present, and Future

Michele Bertolotto, Orlando Catalano

Research output: Contribution to journalArticlepeer-review


The introduction of ultrasound contrast agents (UCAs) is a major advance in sonographic imaging after the development of Doppler techniques. Various clinical applications have been suggested for contrast-enhanced ultrasound (CEUS) in radiological and cardiologic imaging. The commercialization of UCAs in different countries and the development of several scanning technologies have created a need for standardization of methodology and terminology. This article reviews the historical and physical basis of CEUS, illustrates the hepatic and extrahepatic applications, and discusses forthcoming developments.

Original languageEnglish
Pages (from-to)339-367
Number of pages29
JournalUltrasound Clinics
Issue number3
Publication statusPublished - Jul 2009


  • Contrast media
  • Liver
  • Microbubbles
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


Dive into the research topics of 'Contrast-enhanced Ultrasound: Past, Present, and Future'. Together they form a unique fingerprint.

Cite this