Contrast enhancement and the acute lesion in multiple sclerosis

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Gadolinium-enhanced MR imaging has provided relevant information about the inflammatory events related to MS lesion formation. Cell-specific imaging techniques and multipararmetic MR imaging studies should increase our understanding of the pathologic steps between inflammation and irreversible tissue loss, and, as a consequence, our understanding of the mechanisms leading to irreversible neurologic disability in MS. The clinical applications of Gd-enhanced MR imaging should include the diagnostic work-up of MS patients and the assessment of their disease activity over time in the context of natural history studies or clinical trials. Because of the its ability to show the dissemination of lesion over time and its high predictive value for subsequent evolution to clinically definite MS Gd-enhanced MR imaging should be obtained at presentation in those patients with clinically isolated neurologic syndromes. In patients with established MS, however, the usefulness of Gd-enhanced MR imaging depends solely on specific clinical settings of research questions.

Original languageEnglish
Pages (from-to)705-715
Number of pages11
JournalNeuroimaging Clinics of North America
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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