Contrast imaging techniques to diagnose hepatocellular carcinoma in cirrhotics outside regular surveillance

Massimo Iavarone, Mauro Viganò, Nicole Piazza, Vincenzo Occhipinti, Angelo Sangiovanni, Marco Maggioni, Gioacchino D'Ambrosio, Laura V. Forzenigo, Fabio Motta, Pietro Lampertico, Maria Grazia Rumi, Massimo Colombo

Research output: Contribution to journalArticle

Abstract

INTRODUCTION AND AIM: The American Association for the Study of the Liver (AASLD) recommends contrast computerized tomography (CT-scan) and magnetic resonance (MRI) to diagnose hepatocellular carcinoma (HCC) arising in cirrhotic patients under semiannual surveillance with abdominal ultrasound (US). A US guided fine needle biopsy (FNB) serves the same purpose in radiologically undiagnosed tumors and incidentally detected nodules in cirrhotics outside surveillance. In this population, we evaluated the performance of radiological diagnosis of HCC according to 2010 AASLD recommendations. MATERIALS AND METHODS: All cirrhotic patients with a liver nodule incidentally detected by US were prospectively investigated with a sequential application of CT-scan/MRI examination and a FNB. RESULTS: Between 2011 and 2015, 94 patients (mean age 67 years) had a liver nodule (total 120) detected by US in the context of histologically confirmed cirrhosis. Mean nodules diameter was 40 (10-160) mm, 87 (73%) 200ng/mL was 12% (IC95%: 6-23%). CONCLUSION: A single contrast imaging technique showing a typical contrast pattern confidently identifies HCC also in cirrhotic patients with an incidental liver nodule, thereby reducing the need for FNB examinations.
Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalAnnals of Hepatology
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 1 2019

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Keywords

  • Abdominal ultrasound
  • Contrast-enhanced CT-scan
  • Fine needle liver biopsy
  • Intra-hepatic cholangiocarcinoma
  • Magnetic resonance

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