Contrast medium dose-to-GFR ratio: A measure of systemic exposure to predict contrast-induced nephropathy after percutaneous coronary intervention

U. Nyman, J. Björk, P. Aspelin, G. Marenzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The contrast medium (CM) dose-to-eGFR (estimated glomerular filtration rate) ratio has recently been advocated to express systemic exposure to CM in assessing the risk of contrast medium-induced nephropathy (CIN). Purpose: To evaluate how CIN risk might vary with decreasing eGFR at fixed CM-dose/eGFR ratios and other CIN risk factors, and to find a relatively safe CM-dose/eGFR ratio. Material and Methods: 391 patients underwent primary coronary angioplasty for ST-segment elevation acute myocardial infarction. CM dose (grams iodine; g I), eGFR (ml/min), and preprocedural CIN risk factors were entered into a multiple logistic regression model. From the established statistical model, the probability of CIN (≥44.2 mol/l serum creatinine rise or oliguria/anuria) was calculated at various eGFR levels based on g-I/eGFR ratios of 1:2, 1:1, 2:1, and 3:1. Results: At a g-I/eGFR ratio

Original languageEnglish
Pages (from-to)658-667
Number of pages10
JournalActa Radiologica
Volume49
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Contrast medium
  • Coronary intervention
  • Glomerular filtration rate
  • Nephropathy
  • Renal insufficiency

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Contrast medium dose-to-GFR ratio: A measure of systemic exposure to predict contrast-induced nephropathy after percutaneous coronary intervention'. Together they form a unique fingerprint.

Cite this