Abstract
Background: The contrast medium (CM) dose-to-eGFR (estimated glomerular filtration rate) ratio has recently been advocated to express systemic exposure to CM in assessing the risk of contrast medium-induced nephropathy (CIN). Purpose: To evaluate how CIN risk might vary with decreasing eGFR at fixed CM-dose/eGFR ratios and other CIN risk factors, and to find a relatively safe CM-dose/eGFR ratio. Material and Methods: 391 patients underwent primary coronary angioplasty for ST-segment elevation acute myocardial infarction. CM dose (grams iodine; g I), eGFR (ml/min), and preprocedural CIN risk factors were entered into a multiple logistic regression model. From the established statistical model, the probability of CIN (≥44.2 mol/l serum creatinine rise or oliguria/anuria) was calculated at various eGFR levels based on g-I/eGFR ratios of 1:2, 1:1, 2:1, and 3:1. Results: At a g-I/eGFR ratio
Original language | English |
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Pages (from-to) | 658-667 |
Number of pages | 10 |
Journal | Acta Radiologica |
Volume | 49 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- Contrast medium
- Coronary intervention
- Glomerular filtration rate
- Nephropathy
- Renal insufficiency
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
- Medicine(all)