Abstract
The role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti-S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks. JEM
| Original language | English |
|---|---|
| Pages (from-to) | 657-667 |
| Number of pages | 11 |
| Journal | Journal of Experimental Medicine |
| Volume | 205 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 17 2008 |
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ASJC Scopus subject areas
- Immunology
Cite this
Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity. / Rotta, Gianluca; Matteoli, Gianluca; Mazzini, Elisa; Nuciforo, Paolo; Colombo, Mario P.; Rescigno, Maria.
In: Journal of Experimental Medicine, Vol. 205, No. 3, 17.03.2008, p. 657-667.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
AU - Rotta, Gianluca
AU - Matteoli, Gianluca
AU - Mazzini, Elisa
AU - Nuciforo, Paolo
AU - Colombo, Mario P.
AU - Rescigno, Maria
PY - 2008/3/17
Y1 - 2008/3/17
N2 - The role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti-S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks. JEM
AB - The role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti-S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks. JEM
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UR - http://www.scopus.com/inward/citedby.url?scp=41149112988&partnerID=8YFLogxK
U2 - 10.1084/jem.20071734
DO - 10.1084/jem.20071734
M3 - Article
C2 - 18316416
AN - SCOPUS:41149112988
VL - 205
SP - 657
EP - 667
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 3
ER -