Contribution of abnormal insulin secretion and insulin resistance to the pathogenesis of type 2 diabetes in myotonic dystrophy

Gianluca Perseghin, Andrea Caumo, Cinzia Arcelloni, Stefano Benedini, Roberto Lanzi, Emanuela Pagliato, Lucia Piceni Sereni, Giulio Testolin, Alberto Battezzati, Giancarlo Comi, Mauro Comola, Livio Luzi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE - Myotonic dystrophy (MyD), the most common adult form of muscular dystrophy, is often complicated by diabetes. MyD is dominantly inherited and is due to heterozygosity for a trinucleotide repeat expansion mutation in a protein kinase gene able to induce derangement of RNA metabolism responsible of an aberrant insulin receptor expression. RESEARCH DESIGN AND METHODS - To assess insulin sensitivity and secretion before the onset of diabetes, we studied 10 MyD patients, 10 offspring of type 2 diabetes (OFF), and 10 healthy subjects with no family history of diabetes (control subjects) with dual X-ray energy absorption, euglycemic-hyperinsulinemic clamp (40 mU/[m 2 · min]) combined with infusion of [6,6-D 2]- glucose and oral glucose tolerance test (OGTT). RESULTS - MyD had reduced lean body mass, but peripheral insulin sensitivity was not different to that of control subjects in contrast to OFF, which showed insulin resistance. Insulin secretion, obtained by deconvolution of OGTT data, was also shown to be comparable with that of OFF and control subjects (index of β-cell function = Φ; P = 0.91) even if increased parameters of insulin secretion were found during the first 30 min (Φ 30; P = 0.05) of the oral glucose challenge. Fasting plasma proinsulin concentrations (P = 0.01) and the ratio to insulin (P = 0.01) were increased in MyD patients. The proinsulin levels also failed to be suppressed during the clamp and showed exaggerated response after the OGTT. Increased proinsulin levels were shown to be peculiar of MyD patients when compared with OFF. CONCLUSIONS - In nondiabetic, young MyD patients, insulin sensitivity was preserved, and an increased early secretory response to oral glucose was detected. Abnormal plasma pro-insulin levels in the fasting state, during the clamp, and during the OGTT were shown to be secretory dysfunctions peculiar of MyD patients and may be more important than insulin resistance in determining the high risk to develop diabetes in these patients.

Original languageEnglish
Pages (from-to)2112-2118
Number of pages7
JournalDiabetes Care
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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