Abstract
It is well established that many tissue-derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article summarizes some of the recent advances in our understanding of the role of endothelial cells as effector cells in organ formation.
Original language | English |
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Pages (from-to) | 415-427 |
Number of pages | 13 |
Journal | Journal of Anatomy |
Volume | 211 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2007 |
Keywords
- Angiogenesis
- Endothelial cells
- Organ formation
- Signalling pathways
- Vasculogenesis
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Anatomy