Contribution of endothelial cells to organogenesis: A modern reappraisal of an old Aristotelian concept

Enrico Crivellato, B. Nico, D. Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

It is well established that many tissue-derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article summarizes some of the recent advances in our understanding of the role of endothelial cells as effector cells in organ formation.

Original languageEnglish
Pages (from-to)415-427
Number of pages13
JournalJournal of Anatomy
Volume211
Issue number4
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Angiogenesis
  • Endothelial cells
  • Organ formation
  • Signalling pathways
  • Vasculogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

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