Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: Effects of physical training

Massimo Piepoli, Andrew L. Clark, Maurizio Volterrani, Stamatis Adamopoulos, Peter Sleight, Andrew J S Coats

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A neural linkage between peripheral abnormalities and the exaggerated exercise responses in chronic heart failure (CHF) was postulated. We studied the ergoreceptors (afferents sensitive to skeletal muscle work) in CHF and whether training can affect their activity. Methods and Results: In 12 stable CHF patients (ejection fraction [EF] = 26.4%) and 10 control subjects (EF=55.3%), we compared the responses to dynamic handgrip and during a 3-minute period of posthandgrip regional circulatory occlusion (PH-RCO). The ergoreflex contribution was quantified as the percentage responses to exercise maintained by PH-RCO compared with recovery without PH-RCO. Patients showed ergoreflex overactivation compared with control subjects in terms of ventilation (86.5% versus 54.5%), diastolic pressure (97.8% versus 53.5%), and leg vascular resistance (108.1% versus 48.9%) (all P

Original languageEnglish
Pages (from-to)940-952
Number of pages13
JournalCirculation
Volume93
Issue number5
Publication statusPublished - Mar 1 1996

Keywords

  • exercise
  • heart failure
  • muscles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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