Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis

Kenichi Fujii, Gary S. Mintz, Yoshio Kobayashi, Stéphane G. Carlier, Hideo Takebayashi, Takenori Yasuda, Issam Moussa, George Dangas, Roxana Mehran, Alexandra J. Lansky, Arlene Reyes, Edward Kreps, Michael Collins, Antonio Colombo, Gregg W. Stone, Paul S. Teirstein, Martin B. Leon, Jeffrey W. Moses

Research output: Contribution to journalArticle

Abstract

Background-We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR). Methods and Results-Forty-eight ISR lesions (41 patients with objective evidence of ischemia) were treated with SES. Recurrent ISR was identified in 11 lesions (all focal); repeat revascularization was performed in 10. These were compared with 16 patients (19 lesions) without recurrence as documented by angiography. Nine of 11 recurrent lesions had a minimum stent area (MSA) 2 versus 5 of 19 nonrecurrent lesions (P=0.003) ; 7 of 11 recurrent lesions had an MSA 2 versus 4 of 19 nonrecurrent lesions (P=0.02); and 4 of 11 recurrent lesions had an MSA 2 versus 1 of 19 nonrecurrent lesions (P=0.03). A gap between SESs was identified in 3 of 11 recurrences versus 1 of 19 nonrecurrent lesions. Conclusions-Stent underexpansion is a significant cause of failure after SES implantation treatment of ISR.

Original languageEnglish
Pages (from-to)1085-1088
Number of pages4
JournalCirculation
Volume109
Issue number9
DOIs
Publication statusPublished - Mar 9 2004

Keywords

  • Restenosis
  • Stents
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Fujii, K., Mintz, G. S., Kobayashi, Y., Carlier, S. G., Takebayashi, H., Yasuda, T., Moussa, I., Dangas, G., Mehran, R., Lansky, A. J., Reyes, A., Kreps, E., Collins, M., Colombo, A., Stone, G. W., Teirstein, P. S., Leon, M. B., & Moses, J. W. (2004). Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis. Circulation, 109(9), 1085-1088. https://doi.org/10.1161/01.CIR.0000121327.67756.19