Contribution of transjugular liver biopsy in patients with the clinical presentation of acute liver failure

Roberto Miraglia, Angelo Luca, Salvatore Gruttadauria, Marta Ida Minervini, Giovanni Vizzini, Antonio Arcadipane, Bruno Gridelli

Research output: Contribution to journalArticlepeer-review


Purpose: Acute liver failure (ALF) treated with conservative therapy has a poor prognosis, although individual survival varies greatly. In these patients, the eligibility for liver transplantation must be quickly decided. The aim of this study was to assess the role of transjugular liver biopsy (TJLB) in the management of patients with the clinical presentation of ALF. Methods: Seventeen patients with the clinical presentation of ALF were referred to our institution during a 52 month period. A TJLB was performed using the Cook Quick-Core needle biopsy. Clinical data, procedural complications, and histologic findings were evaluated. Results: Causes of ALF were virus hepatitis B infection in 7 patients, drug toxicity in 4, mushroom in 1, Wilson's disease in 1, and unknown origin in 4. TJLB was technically successful in all patients without procedure-related complications. Tissue specimens were satisfactory for diagnosis in all cases. In 14 of 17 patients the initial clinical diagnosis was confirmed by TJLB; in 3 patients the initial diagnosis was altered by the presence of unknown cirrhosis. Seven patients with necrosis

Original languageEnglish
Pages (from-to)1008-1010
Number of pages3
JournalCardioVascular and Interventional Radiology
Issue number6
Publication statusPublished - Dec 2006


  • Acute liver failure
  • Liver transplantation
  • Transjugular liver biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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