Translated title of the contribution: Contribution to the discussion of epileptic drop attacks

G. Avanzini

Research output: Contribution to journalArticlepeer-review


The discussion is here restricted to atonic (astatic) seizures leading the subject to slump to the ground because of a sudden loss of postural tone. Atonic seizures are due to primarily or secondarily generalized discharges with a suppressive effect on postural tone. Atonic and myoclonic phenomenology can be associated in the same subject either in combination (myoclono-atonic seizures) or independently and are thought to share some common pathophysiological mechanisms. Experimental observations suggest that atonic or myoclonic effects are to be expected to occur depending on the selective involvement of superficial or deep cortical layers respectively. Moreover, the final effect on extensor muscles depends on the functional status of subcortical mechanisms responsible for muscle tone which the corticofugal discharge impinge upon. In view of the complexity of postural mechanisms putatively involved in the pathophysiology of atonic seizures claims of a specific indication of callosotomy in intractable atonic seizures should be considered with caution.

Translated title of the contributionContribution to the discussion of epileptic drop attacks
Original languageItalian
Pages (from-to)37-38
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number82-83
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Clinical Neurology


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