Contributo allo studio radiologico del granuloma eosinofilo della mandibola (granuloma unifocale da istiocitosi delle cellule di Langerhans)

Translated title of the contribution: Contribution to the radiological study of the eosinophilic granuloma of the mandible (unifocal granuloma due to Langherans' cell histiocytosis)

Gino Ghigi, Alessandro Pastremoli, Giuseppe Bianchi, Paolo Pisi, Alfredo Pastremoli

Research output: Contribution to journalArticle

Abstract

Purpose. The radiological diagnosis of osteolytic lesions of the mandible still constitutes a challenge in some pathological conditions in which the clinical data and the case history are relatively uniform and the radiological picture is lacking in any characteristics. Materials and methods. We reviewed the conventional radiograms of six cases of Langherans' cell histiocytosis (LCH) of the mandible examined over the last ten years. The X-ray examinations were performed in the lateral-oblique projection to allow a view of the horizontal portion of the mandible almost completely free of overlapping images of other bone structures. Results. We identified a series of radiological patterns for these reticulo-endotheliopathies capable of causing granuloma formed by polinuclear eosinophils, plasma cells, lymphocytes, and large mononuclear macrophages with granulopexic and phagocytic activity that proliferate in the bone tissue and can be identified as the Langherans' cells of skin, mucosa, periodontal cavities and bone marrow. The granulomatous tissue penetrates the affected organ elements and, in its spread, it compresses, atrophies, and destroys the damaged tissue, replacing it. The alterations produced by Langherans' cell histiocytic granuloma are most common in the skeletal system affecting, in order of frequency, the skull, the long bones of the limbs, the foot, the ribs and the spine. The oral mucosa is rarely involved. Conclusions. The radiological investigation of unifocal Langherans' cell histiocytic granuloma of the mandible is essential in the study of perimandibular swelling, although diagnosis is based on biopsy alone. In addition to digital or conventional radiography, other useful examinations are bone scintigraphy, Colour Doppler US, MR and CT, which enables a correct localisation necessary for planning the biopsy and treatment.

Translated title of the contributionContribution to the radiological study of the eosinophilic granuloma of the mandible (unifocal granuloma due to Langherans' cell histiocytosis)
Original languageItalian
Pages (from-to)414-420
Number of pages7
JournalRadiologia Medica
Volume109
Issue number4
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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