Contributions of food, bile and pancreatic juice to intestinal adaptation in rats

A. Andriulli, A. Bargoni, C. M. Fronticelli

Research output: Contribution to journalArticle

Abstract

The study evaluates the adaptive changes in the duodenum, jejunum and ileum inducted by diverting food or pancreatico-biliary secretions to the mid-small bowel without intestinal resections in rats. Following food diversion to the mid-intestine, with preservation of the physiological transit of pancreatico-biliary effluents, body weight decreased as did the weight of tissues proximally located to the surgical bypass. After either bile or pancreatic juice diversion, rats gained weight while both duodenal and jejunal mucosa was grossly unaffected. Following concomitant diversion of biliary-pancreatic secretions, the weight of both duodenal and proximal jejunal tissues increased while the influence of the procedure on body weight varied from animal to animal. The results indicate that transit of food in the upper gastrointestinal tract plays a dominant role in maintaining the normal trophism of tissues and animals. After all types of surgical bypasses, a definite increase in the ileal weight was observed; greater changes were found after both pancreatic and biliopancreatic diversion compared to bile diversion, suggesting that bile alone exerts a limited trophic effect on ileal mucosa, whereas the presence of pancreatic juice strengthens the ileal adaptive response. The duodenal and jejunal increase seen after bilio-pancreatic diversion is evidence in favour of a hormonal contribution to the control of intestinal adaptation.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalItalian Journal of Gastroenterology
Volume17
Issue number3
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Gastroenterology

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