Abstract
Toxicology is a discipline which employs a series of tests to predict the toxic effects of drugs in man. This prediction is made by extrapolating data from animal studies and - with a number of notable exceptions - has been relatively useful in developing new drugs. There is still room for considerable improvement, however, in the available methods. In synthesis, the toxic effect of a drug depends on two major components: the concentration present at the target site and the sensitivity of the target site. These are both subject to important changes in relation to a large number of variables including the animal species, strain, age, the environment, and the pathology. This paper concentrates on one of these components, the levels of the drug at the target site; the discipline involved in these studies is known as toxicokinetics and shares various methods with pharmacokinetics.
| Original language | English |
|---|---|
| Pages (from-to) | 255-258 |
| Number of pages | 4 |
| Journal | Drug Information Journal |
| Volume | 28 |
| Issue number | 1 |
| Publication status | Published - 1994 |
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Keywords
- Concentrations
- Dose
- Toxicokinetics
ASJC Scopus subject areas
- Health Informatics
- Public Health, Environmental and Occupational Health
- Nursing(all)
- Pharmacology
Cite this
Contributions of toxicokinetics to toxicology of drugs. / Garattini, S.
In: Drug Information Journal, Vol. 28, No. 1, 1994, p. 255-258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contributions of toxicokinetics to toxicology of drugs
AU - Garattini, S.
PY - 1994
Y1 - 1994
N2 - Toxicology is a discipline which employs a series of tests to predict the toxic effects of drugs in man. This prediction is made by extrapolating data from animal studies and - with a number of notable exceptions - has been relatively useful in developing new drugs. There is still room for considerable improvement, however, in the available methods. In synthesis, the toxic effect of a drug depends on two major components: the concentration present at the target site and the sensitivity of the target site. These are both subject to important changes in relation to a large number of variables including the animal species, strain, age, the environment, and the pathology. This paper concentrates on one of these components, the levels of the drug at the target site; the discipline involved in these studies is known as toxicokinetics and shares various methods with pharmacokinetics.
AB - Toxicology is a discipline which employs a series of tests to predict the toxic effects of drugs in man. This prediction is made by extrapolating data from animal studies and - with a number of notable exceptions - has been relatively useful in developing new drugs. There is still room for considerable improvement, however, in the available methods. In synthesis, the toxic effect of a drug depends on two major components: the concentration present at the target site and the sensitivity of the target site. These are both subject to important changes in relation to a large number of variables including the animal species, strain, age, the environment, and the pathology. This paper concentrates on one of these components, the levels of the drug at the target site; the discipline involved in these studies is known as toxicokinetics and shares various methods with pharmacokinetics.
KW - Concentrations
KW - Dose
KW - Toxicokinetics
UR - http://www.scopus.com/inward/record.url?scp=0027993538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027993538&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027993538
VL - 28
SP - 255
EP - 258
JO - Drug Information Journal
JF - Drug Information Journal
SN - 0092-8615
IS - 1
ER -