Control of a cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity

Paul Fisch, Eva Meuer, Daniela Pende, Simon Rothenfußer, Oriane Viale, Sylvia Kock, Soldano Ferrone, Didier Fradelizi, George Klein, Lorenzo Moretta, Hans Georg Rammensee, Thierry Boon, Pierre Coulie, Pierre Van Der Bruggen

Research output: Contribution to journalArticlepeer-review

Abstract

The Vγ9/Vδ2 T cell receptor (TCR) is expressed by most human γδ T cells. We show here that cytotoxic T lymphocytes of the Vγ9/Vδ2 subset, but not of the Vδ1 subset of human γδ T cells, express natural killer inhibitory receptors (KIR) with specificity for different HLA class I alleles that down-regulate TCR-mediated signaling in response to HLA class I-expressing B cell lymphomas. Vγ9/Vδ2 T cell clones with a T helper cell phenotype lack KIR and produce lymphokines in response to most human B cell lymphomas, just as they do upon recognition of the HLA class I-deficient human Burkitt's lymphoma Daudi. Thus, human Vγ9/Vδ2 T cells have an innate specificity for nonpolymorphic cell surface structures expressed by many lymphoma cells and their cytotoxic activity is controlled by KIR. These results imply a general role of human Vγ9/Vδ2 T cells in the defense against hematopoietic tumors that is distinct from NK cells.

Original languageEnglish
Pages (from-to)3368-3379
Number of pages12
JournalEuropean Journal of Immunology
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 1997

Keywords

  • γδ T lymphocyte
  • B cell lymphoma
  • Natural killer receptor

ASJC Scopus subject areas

  • Immunology

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