Control of breathing in patients with short-term primary hypothyroidism

M. Gorini; A. Spinelli; C. Cangioli; F. Gigliotti; R. Duranti; P. Arcangeli; G. Scano

doi:10.1007/BF02714929

Control of breathing in patients with short-term primary hypothyroidism

M. Gorini, A. Spinelli, C. Cangioli, F. Gigliotti, R. Duranti, P. Arcangeli, G. Scano

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P_0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO₂ rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO₂ tension (ΔEMGd/ΔPetCO₂ and ΔVE/ΔPetCO₂), but significantly less ΔP_0.1/ΔPetCO₂ (p2 (p3), Pimax (p0.1/ΔPetCO₂, and Δ(Vt/Ti)/ΔPetCO₂ response slopes were found to be significantly increased (p3 increases both force (P_0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.

Original language	English
Pages (from-to)	43-53
Number of pages	11
Journal	Lung
Volume	167
Issue number	1
DOIs	https://doi.org/10.1007/BF02714929
Publication status	Published - Dec 1989

Keywords

Breathing control
diaphragmatic
Electromyography
Hypothyroidism
L-triiodothyronine replacement therapy
Mouth occlusion pressure

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Physiology

Access to Document

10.1007/BF02714929

Cite this

@article{4b4b20390e724cb0abaa19ac773efdc6,

title = "Control of breathing in patients with short-term primary hypothyroidism",

abstract = "In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.",

keywords = "Breathing control, diaphragmatic, Electromyography, Hypothyroidism, L-triiodothyronine replacement therapy, Mouth occlusion pressure",

author = "M. Gorini and A. Spinelli and C. Cangioli and F. Gigliotti and R. Duranti and P. Arcangeli and G. Scano",

year = "1989",

month = dec,

doi = "10.1007/BF02714929",

language = "English",

volume = "167",

pages = "43--53",

journal = "Lung",

issn = "0341-2040",

publisher = "Springer New York",

number = "1",

}

TY - JOUR

T1 - Control of breathing in patients with short-term primary hypothyroidism

AU - Gorini, M.

AU - Spinelli, A.

AU - Cangioli, C.

AU - Gigliotti, F.

AU - Duranti, R.

AU - Arcangeli, P.

AU - Scano, G.

PY - 1989/12

Y1 - 1989/12

N2 - In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.

AB - In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.

KW - Breathing control

KW - diaphragmatic

KW - Electromyography

KW - Hypothyroidism

KW - L-triiodothyronine replacement therapy

KW - Mouth occlusion pressure

UR - http://www.scopus.com/inward/record.url?scp=0024504948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024504948&partnerID=8YFLogxK

U2 - 10.1007/BF02714929

DO - 10.1007/BF02714929

M3 - Article

C2 - 2493534

AN - SCOPUS:0024504948

VL - 167

SP - 43

EP - 53

JO - Lung

JF - Lung

SN - 0341-2040

IS - 1

ER -

Control of breathing in patients with short-term primary hypothyroidism

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this