Abstract
In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.
| Original language | English |
|---|---|
| Pages (from-to) | 43-53 |
| Number of pages | 11 |
| Journal | Lung |
| Volume | 167 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1989 |
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Keywords
- Breathing control
- diaphragmatic
- Electromyography
- Hypothyroidism
- L-triiodothyronine replacement therapy
- Mouth occlusion pressure
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Physiology
Cite this
Control of breathing in patients with short-term primary hypothyroidism. / Gorini, M.; Spinelli, A.; Cangioli, C.; Gigliotti, F.; Duranti, R.; Arcangeli, P.; Scano, G.
In: Lung, Vol. 167, No. 1, 12.1989, p. 43-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Control of breathing in patients with short-term primary hypothyroidism
AU - Gorini, M.
AU - Spinelli, A.
AU - Cangioli, C.
AU - Gigliotti, F.
AU - Duranti, R.
AU - Arcangeli, P.
AU - Scano, G.
PY - 1989/12
Y1 - 1989/12
N2 - In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.
AB - In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.
KW - Breathing control
KW - diaphragmatic
KW - Electromyography
KW - Hypothyroidism
KW - L-triiodothyronine replacement therapy
KW - Mouth occlusion pressure
UR - http://www.scopus.com/inward/record.url?scp=0024504948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024504948&partnerID=8YFLogxK
U2 - 10.1007/BF02714929
DO - 10.1007/BF02714929
M3 - Article
VL - 167
SP - 43
EP - 53
JO - Lung
JF - Lung
SN - 0341-2040
IS - 1
ER -