Control of breathing in patients with short-term primary hypothyroidism

M. Gorini, A. Spinelli, C. Cangioli, F. Gigliotti, R. Duranti, P. Arcangeli, G. Scano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In 8 patients (3 men and 5 women) with short-term primary hypothyroidism before and during replacement therapy, and in an age-matched control group (9 men and 7 women), we assessed maximal inspiratory muscle force (Pimax) and the ventilatory control system at neural (EMG), muscular (P0.1), and ventilatory (VE and Vt/Ti) levels. While hypothyroid, patients exhibited a significantly lower Pimax. During a CO2 rebreathing test, hypothyroid patients exhibited similar diaphragmatic electromyographic (EMGd) and ventilatory (VE) response slopes to increasing end-tidal CO2 tension (ΔEMGd/ΔPetCO2 and ΔVE/ΔPetCO2), but significantly less ΔP0.1/ΔPetCO2 (p2 (p3), Pimax (p0.1/ΔPetCO2, and Δ(Vt/Ti)/ΔPetCO2 response slopes were found to be significantly increased (p3 increases both force (P0.1 and Pimax) and velocity (Vt/Ti) of inspiratory muscle contraction.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalLung
Volume167
Issue number1
DOIs
Publication statusPublished - Dec 1989

Fingerprint

Hypothyroidism
Respiration
Muscle Contraction
Research Design
Muscles
Control Groups
Therapeutics

Keywords

  • Breathing control
  • diaphragmatic
  • Electromyography
  • Hypothyroidism
  • L-triiodothyronine replacement therapy
  • Mouth occlusion pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Gorini, M., Spinelli, A., Cangioli, C., Gigliotti, F., Duranti, R., Arcangeli, P., & Scano, G. (1989). Control of breathing in patients with short-term primary hypothyroidism. Lung, 167(1), 43-53. https://doi.org/10.1007/BF02714929

Control of breathing in patients with short-term primary hypothyroidism. / Gorini, M.; Spinelli, A.; Cangioli, C.; Gigliotti, F.; Duranti, R.; Arcangeli, P.; Scano, G.

In: Lung, Vol. 167, No. 1, 12.1989, p. 43-53.

Research output: Contribution to journalArticle

Gorini, M, Spinelli, A, Cangioli, C, Gigliotti, F, Duranti, R, Arcangeli, P & Scano, G 1989, 'Control of breathing in patients with short-term primary hypothyroidism', Lung, vol. 167, no. 1, pp. 43-53. https://doi.org/10.1007/BF02714929
Gorini M, Spinelli A, Cangioli C, Gigliotti F, Duranti R, Arcangeli P et al. Control of breathing in patients with short-term primary hypothyroidism. Lung. 1989 Dec;167(1):43-53. https://doi.org/10.1007/BF02714929
Gorini, M. ; Spinelli, A. ; Cangioli, C. ; Gigliotti, F. ; Duranti, R. ; Arcangeli, P. ; Scano, G. / Control of breathing in patients with short-term primary hypothyroidism. In: Lung. 1989 ; Vol. 167, No. 1. pp. 43-53.
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