Control of ColE1 plasmid replication by antisense RNA

G. Cesareni, M. Helmer-Citterich, L. Castagnoli

Research output: Contribution to journalArticlepeer-review

Abstract

One of the two major classes of regulatory strategies that control plasmid copy number involves recognition via base pairing between two plasmid-encoded complementary RNAs. The detailed analysis of this control circuitry has revealed some features of regulatory mechanisms based on RNA-RNA interaction that distinguish then from those based on protein-nucleic acid interaction. These features provide a framework with which to understand other regulatory mechanisms based on RNA-RNA interaction, and will aid in the design of efficient artificial antisense RNA systems.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalTrends in Genetics
Volume7
Issue number7
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Genetics

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