The atypical chemokine receptor D6 is a decoy and scavenger receptor for most inflammatory CC chemokines and prevents the development of exacerbated inflammatory reactions. Here we report that mice lacking D6 expression in the nonhematopoietic compartment have a selective increase in the number of Ly6C high monocytes in the circulation and in secondary lymphoid tissues. Under inflammatory conditions, Ly6C high monocytes accumulate in increased number in secondary lymphoid organs of D6 -/- mice in a CCR2-dependent manner. Ly6Chigh monocytes derived from D6 -/- mice have enhanced immunosuppressive activity, inhibit the development of adaptive immune responses, and partially protect mice from the development of GVHD. Thus, control of CCR2 ligands by D6 regulates the traffic of Ly6C high monocytes and controls their immunosuppressive potential.
ASJC Scopus subject areas
- Cell Biology