Abstract
Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show that vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4+ T-cell decrease. These results may provide new opportunities for the development of a vaccine against AIDS.
| Original language | English |
|---|---|
| Pages (from-to) | 643-650 |
| Number of pages | 8 |
| Journal | Nature Medicine |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1999 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine. / Cafaro, Aurelio; Caputo, Antonella; Fracasso, Claudio; Maggiorella, Maria T.; Goletti, Delia; Baroncelli, Silvia; Pace, Monica; Sernicola, Leonardo; Koanga-Mogtomo, Martin L.; Betti, Monica; Borsetti, Alessandra; Belli, Roberto; Åkerblom, Lennart; Corrias, Franco; Buttò, Stefano; Heeney, Jonathan; Verani, Paola; Titti, Fausto; Ensoli, Barbara.
In: Nature Medicine, Vol. 5, No. 6, 06.1999, p. 643-650.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
AU - Cafaro, Aurelio
AU - Caputo, Antonella
AU - Fracasso, Claudio
AU - Maggiorella, Maria T.
AU - Goletti, Delia
AU - Baroncelli, Silvia
AU - Pace, Monica
AU - Sernicola, Leonardo
AU - Koanga-Mogtomo, Martin L.
AU - Betti, Monica
AU - Borsetti, Alessandra
AU - Belli, Roberto
AU - Åkerblom, Lennart
AU - Corrias, Franco
AU - Buttò, Stefano
AU - Heeney, Jonathan
AU - Verani, Paola
AU - Titti, Fausto
AU - Ensoli, Barbara
PY - 1999/6
Y1 - 1999/6
N2 - Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show that vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4+ T-cell decrease. These results may provide new opportunities for the development of a vaccine against AIDS.
AB - Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show that vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4+ T-cell decrease. These results may provide new opportunities for the development of a vaccine against AIDS.
UR - http://www.scopus.com/inward/record.url?scp=0033026062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033026062&partnerID=8YFLogxK
U2 - 10.1038/9488
DO - 10.1038/9488
M3 - Article
C2 - 10371502
AN - SCOPUS:0033026062
VL - 5
SP - 643
EP - 650
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 6
ER -