Control of SIV rebound through structured treatment interruptions during early infection

F. Lori, M. G. Lewis, J. Xu, G. Varga, Jr Zinn D.E., C. Crabbs, W. Wagner, J. Greenhouse, P. Silvera, J. Yalley-Ogunro, C. Tinelli, J. Lisziewicz

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SlY rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalScience
Volume290
Issue number5496
Publication statusPublished - Nov 24 2000

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Simian Immunodeficiency Virus
Highly Active Antiretroviral Therapy
Infection
Sexually Transmitted Diseases
Therapeutics
Appointments and Schedules
Viruses
Macaca
Viral Load
Randomized Controlled Trials
T-Lymphocytes

ASJC Scopus subject areas

  • General

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Lori, F., Lewis, M. G., Xu, J., Varga, G., Zinn D.E., J., Crabbs, C., ... Lisziewicz, J. (2000). Control of SIV rebound through structured treatment interruptions during early infection. Science, 290(5496), 1591-1593.

Control of SIV rebound through structured treatment interruptions during early infection. / Lori, F.; Lewis, M. G.; Xu, J.; Varga, G.; Zinn D.E., Jr; Crabbs, C.; Wagner, W.; Greenhouse, J.; Silvera, P.; Yalley-Ogunro, J.; Tinelli, C.; Lisziewicz, J.

In: Science, Vol. 290, No. 5496, 24.11.2000, p. 1591-1593.

Research output: Contribution to journalArticle

Lori, F, Lewis, MG, Xu, J, Varga, G, Zinn D.E., J, Crabbs, C, Wagner, W, Greenhouse, J, Silvera, P, Yalley-Ogunro, J, Tinelli, C & Lisziewicz, J 2000, 'Control of SIV rebound through structured treatment interruptions during early infection', Science, vol. 290, no. 5496, pp. 1591-1593.
Lori F, Lewis MG, Xu J, Varga G, Zinn D.E. J, Crabbs C et al. Control of SIV rebound through structured treatment interruptions during early infection. Science. 2000 Nov 24;290(5496):1591-1593.
Lori, F. ; Lewis, M. G. ; Xu, J. ; Varga, G. ; Zinn D.E., Jr ; Crabbs, C. ; Wagner, W. ; Greenhouse, J. ; Silvera, P. ; Yalley-Ogunro, J. ; Tinelli, C. ; Lisziewicz, J. / Control of SIV rebound through structured treatment interruptions during early infection. In: Science. 2000 ; Vol. 290, No. 5496. pp. 1591-1593.
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