Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection

Sonia Coni, Paola Infante, Alberto Gulino

Research output: Contribution to journalArticlepeer-review

Abstract

Hedgehog is a key morphogen regulating embryonic development and tissue repair. Remarkably, when misregulated, it leads to tumorigenesis. Hedgehog signaling is triggered by binding of ligands with transmembrane receptor Ptch and is subsequently mediated by transcriptional effectors belonging to the Gli family, whose functions is tuned by a number of molecular interactions and post-synthetic modifications. The complex of these regulatory circuitries provides a tight control of developmental processes, mainly involving the modulation of genes determining the fate of stem cells. Similarly, Hedgehog regulates cancer stem cells fostering tumorigenesis. To this regard, these processes represent promising targets for novel therapeutic strategies aiming at the control of stemness reactivation and maintenance in cancer.

Original languageEnglish
Pages (from-to)623-628
Number of pages6
JournalBiochemical Pharmacology
Volume85
Issue number5
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Cancer
  • Gli
  • Gli-antagonists
  • Hedgehog
  • Smo-antagonists
  • Stem cell

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

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