Abstract
Background and Aims: Antibiotic prophylaxis in severe pancreatitis has recently yielded promising clinical results, with imipenem significantly reducing the incidence of infected necrosis compared with an untreated control group. On the bases of pefloxacin's spectrum of action and pancreatic penetration, we investigated whether such drugs represent a valid alternative to imipenem. Methods: In a multicenter study, 60 patients with severe acute pancreatitis with necrosis affecting at least 50% of the pancreas were randomly allocated to receive intravenous treatment for 2 weeks with pefloxacin, 400 mg twice daily (30 patients), or imipenem, 500 mg three times daily (30 patients), within 120 hours of onset of symptoms. Age, sex, body weight, Ranson and Apache II scores, C-reactive protein, etiology, and time from onset of symptoms to treatment were well matched in the two groups. Results: The incidences of infected necrosis and extrapancreatic infections were 34% and 44%, respectively, in the pefloxacin group and 10% and 20% in the imipenem group. Imipenem proved significantly more effective in prevention of pancreatic infections (P ≤ 0.05). Mortality was not significantly different in the two groups. Conclusions: Despite its theoretical potential, pefloxacin is inferior to imipenem in the prevention of infections associated with severe pancreatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1513-1517 |
| Number of pages | 5 |
| Journal | Gastroenterology |
| Volume | 115 |
| Issue number | 6 |
| Publication status | Published - 1998 |
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ASJC Scopus subject areas
- Gastroenterology
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Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis. / Bassi, C.; Falconi, M.; Talamini, G.; Uomo, G.; Papaccio, G.; Dervenis, C.; Salvia, R.; Minelli, E. B.; Pederzoli, P.
In: Gastroenterology, Vol. 115, No. 6, 1998, p. 1513-1517.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis
AU - Bassi, C.
AU - Falconi, M.
AU - Talamini, G.
AU - Uomo, G.
AU - Papaccio, G.
AU - Dervenis, C.
AU - Salvia, R.
AU - Minelli, E. B.
AU - Pederzoli, P.
PY - 1998
Y1 - 1998
N2 - Background and Aims: Antibiotic prophylaxis in severe pancreatitis has recently yielded promising clinical results, with imipenem significantly reducing the incidence of infected necrosis compared with an untreated control group. On the bases of pefloxacin's spectrum of action and pancreatic penetration, we investigated whether such drugs represent a valid alternative to imipenem. Methods: In a multicenter study, 60 patients with severe acute pancreatitis with necrosis affecting at least 50% of the pancreas were randomly allocated to receive intravenous treatment for 2 weeks with pefloxacin, 400 mg twice daily (30 patients), or imipenem, 500 mg three times daily (30 patients), within 120 hours of onset of symptoms. Age, sex, body weight, Ranson and Apache II scores, C-reactive protein, etiology, and time from onset of symptoms to treatment were well matched in the two groups. Results: The incidences of infected necrosis and extrapancreatic infections were 34% and 44%, respectively, in the pefloxacin group and 10% and 20% in the imipenem group. Imipenem proved significantly more effective in prevention of pancreatic infections (P ≤ 0.05). Mortality was not significantly different in the two groups. Conclusions: Despite its theoretical potential, pefloxacin is inferior to imipenem in the prevention of infections associated with severe pancreatitis.
AB - Background and Aims: Antibiotic prophylaxis in severe pancreatitis has recently yielded promising clinical results, with imipenem significantly reducing the incidence of infected necrosis compared with an untreated control group. On the bases of pefloxacin's spectrum of action and pancreatic penetration, we investigated whether such drugs represent a valid alternative to imipenem. Methods: In a multicenter study, 60 patients with severe acute pancreatitis with necrosis affecting at least 50% of the pancreas were randomly allocated to receive intravenous treatment for 2 weeks with pefloxacin, 400 mg twice daily (30 patients), or imipenem, 500 mg three times daily (30 patients), within 120 hours of onset of symptoms. Age, sex, body weight, Ranson and Apache II scores, C-reactive protein, etiology, and time from onset of symptoms to treatment were well matched in the two groups. Results: The incidences of infected necrosis and extrapancreatic infections were 34% and 44%, respectively, in the pefloxacin group and 10% and 20% in the imipenem group. Imipenem proved significantly more effective in prevention of pancreatic infections (P ≤ 0.05). Mortality was not significantly different in the two groups. Conclusions: Despite its theoretical potential, pefloxacin is inferior to imipenem in the prevention of infections associated with severe pancreatitis.
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M3 - Article
C2 - 9834279
AN - SCOPUS:0031731213
VL - 115
SP - 1513
EP - 1517
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 6
ER -