Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism

Claudia Massarotti, Patrizia Fiorio, Roberto Gastaldi, Lucia Rosaia De Santis, Daniela Pastorino, Valentino Remorgida, Paola Anserini

Research output: Contribution to journalArticle

Abstract

We describe successful controlled ovarian stimulation (COS) and the first known IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism (HH) linked to a chromosome 4 double mutation in the allele of the Gonadotropins Releasing Hormone receptor (GnRHr) gene. Previous administration of low dose of gonadotropins, as recommended in patients with HH, led to poor follicular recruitment. Since trisomy X is a risk factor for diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI), higher doses of gonadotropins led to better ovarian response. The report readknowledges the importance of a correct genetic evaluation in a competent laboratory as a reliable base for treatment planning in this kind of patients.

Original languageEnglish
Pages (from-to)763-765
Number of pages3
JournalGynecological Endocrinology
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 2017

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Hypogonadism
Ovulation Induction
Gonadotropins
LHRH Receptors
Pregnancy
Chromosomes, Human, Pair 4
Alleles
Mutation
Genes
Triple X syndrome
Therapeutics
Ovarian Reserve

Keywords

  • Journal Article

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Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism. / Massarotti, Claudia; Fiorio, Patrizia; Gastaldi, Roberto; Rosaia De Santis, Lucia; Pastorino, Daniela; Remorgida, Valentino; Anserini, Paola.

In: Gynecological Endocrinology, Vol. 33, No. 10, 10.2017, p. 763-765.

Research output: Contribution to journalArticle

Massarotti, Claudia ; Fiorio, Patrizia ; Gastaldi, Roberto ; Rosaia De Santis, Lucia ; Pastorino, Daniela ; Remorgida, Valentino ; Anserini, Paola. / Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism. In: Gynecological Endocrinology. 2017 ; Vol. 33, No. 10. pp. 763-765.
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AU - Remorgida, Valentino

AU - Anserini, Paola

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