Controlled study of the effects of tiropramide on biliary dyskinesia

E. Trabucchi, C. Baratti, A. Centemero, M. Zuin, E. Rizzitelli, R. Colombo

Research output: Contribution to journalArticle

Abstract

A controlled trial was carried out in patients with biliary dyskinesia to compare the effects of the new calmodulin-independent and antispastic drug tiropramide with those of imecromone. Forty patients were randomly divided into two groups, one treated with 300 mg tiropramide per day and the other with 1200 mg imecromone per day, both treatments lasting for 3 months. The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. In subjects with delayed filling of the gall bladder during cholecystography, tiropramide but not imecromone was able to normalize the condition. These results confirm the antispastic synchronizing effect of tiropramide on the motor activity of the gall bladder and the sphincter of Oddi and indicate that it should be the drug of choice for treatment of motor disorders of the biliary tract.

Original languageEnglish
Pages (from-to)541-550
Number of pages10
JournalPharmatherapeutica
Volume4
Issue number9
Publication statusPublished - 1986

Fingerprint

Biliary Dyskinesia
Hymecromone
Urinary Bladder
Cholecystography
Sphincter of Oddi
Pain
Dyspepsia
Biliary Tract
Calmodulin
Pharmaceutical Preparations
Motor Activity
tiropramide
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Trabucchi, E., Baratti, C., Centemero, A., Zuin, M., Rizzitelli, E., & Colombo, R. (1986). Controlled study of the effects of tiropramide on biliary dyskinesia. Pharmatherapeutica, 4(9), 541-550.

Controlled study of the effects of tiropramide on biliary dyskinesia. / Trabucchi, E.; Baratti, C.; Centemero, A.; Zuin, M.; Rizzitelli, E.; Colombo, R.

In: Pharmatherapeutica, Vol. 4, No. 9, 1986, p. 541-550.

Research output: Contribution to journalArticle

Trabucchi, E, Baratti, C, Centemero, A, Zuin, M, Rizzitelli, E & Colombo, R 1986, 'Controlled study of the effects of tiropramide on biliary dyskinesia', Pharmatherapeutica, vol. 4, no. 9, pp. 541-550.
Trabucchi E, Baratti C, Centemero A, Zuin M, Rizzitelli E, Colombo R. Controlled study of the effects of tiropramide on biliary dyskinesia. Pharmatherapeutica. 1986;4(9):541-550.
Trabucchi, E. ; Baratti, C. ; Centemero, A. ; Zuin, M. ; Rizzitelli, E. ; Colombo, R. / Controlled study of the effects of tiropramide on biliary dyskinesia. In: Pharmatherapeutica. 1986 ; Vol. 4, No. 9. pp. 541-550.
@article{732072a9b2404912a45db184c0203ff9,
title = "Controlled study of the effects of tiropramide on biliary dyskinesia",
abstract = "A controlled trial was carried out in patients with biliary dyskinesia to compare the effects of the new calmodulin-independent and antispastic drug tiropramide with those of imecromone. Forty patients were randomly divided into two groups, one treated with 300 mg tiropramide per day and the other with 1200 mg imecromone per day, both treatments lasting for 3 months. The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. In subjects with delayed filling of the gall bladder during cholecystography, tiropramide but not imecromone was able to normalize the condition. These results confirm the antispastic synchronizing effect of tiropramide on the motor activity of the gall bladder and the sphincter of Oddi and indicate that it should be the drug of choice for treatment of motor disorders of the biliary tract.",
author = "E. Trabucchi and C. Baratti and A. Centemero and M. Zuin and E. Rizzitelli and R. Colombo",
year = "1986",
language = "English",
volume = "4",
pages = "541--550",
journal = "Pharmatherapeutica",
issn = "0308-051X",
number = "9",

}

TY - JOUR

T1 - Controlled study of the effects of tiropramide on biliary dyskinesia

AU - Trabucchi, E.

AU - Baratti, C.

AU - Centemero, A.

AU - Zuin, M.

AU - Rizzitelli, E.

AU - Colombo, R.

PY - 1986

Y1 - 1986

N2 - A controlled trial was carried out in patients with biliary dyskinesia to compare the effects of the new calmodulin-independent and antispastic drug tiropramide with those of imecromone. Forty patients were randomly divided into two groups, one treated with 300 mg tiropramide per day and the other with 1200 mg imecromone per day, both treatments lasting for 3 months. The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. In subjects with delayed filling of the gall bladder during cholecystography, tiropramide but not imecromone was able to normalize the condition. These results confirm the antispastic synchronizing effect of tiropramide on the motor activity of the gall bladder and the sphincter of Oddi and indicate that it should be the drug of choice for treatment of motor disorders of the biliary tract.

AB - A controlled trial was carried out in patients with biliary dyskinesia to compare the effects of the new calmodulin-independent and antispastic drug tiropramide with those of imecromone. Forty patients were randomly divided into two groups, one treated with 300 mg tiropramide per day and the other with 1200 mg imecromone per day, both treatments lasting for 3 months. The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. In subjects with delayed filling of the gall bladder during cholecystography, tiropramide but not imecromone was able to normalize the condition. These results confirm the antispastic synchronizing effect of tiropramide on the motor activity of the gall bladder and the sphincter of Oddi and indicate that it should be the drug of choice for treatment of motor disorders of the biliary tract.

UR - http://www.scopus.com/inward/record.url?scp=0022465238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022465238&partnerID=8YFLogxK

M3 - Article

C2 - 2429334

AN - SCOPUS:0022465238

VL - 4

SP - 541

EP - 550

JO - Pharmatherapeutica

JF - Pharmatherapeutica

SN - 0308-051X

IS - 9

ER -